In rats, pretreatment with the mitochondrial reactive oxygen species reducers mitoTEMPO or Bendavia did not abolish the cardioprotective effects of exercise, unlike NADPH oxidase inhibitors.
In plain wordsIn rats, mitochondria-targeted antioxidants, including Bendavia, did not remove the heart protection from exercise, unlike NADPH oxidase blockers.
- Peptide
- Elamipretide (SS-31)
- Outcome
- No significant changeExercise cardioprotection with mitochondrial ROS reducers (mitoTEMPO, Bendavia)
- Study
ratn: not reported in source
Exercise preconditioning, isolated heart ischaemia/reperfusion- Outcome group
- Cardiovascular events · Cardiovascular
Source sentences
The cardioprotective effects of exercise were abolished if animals exercised in the presence of NADPH oxidase inhibitors, in clear contrast to the mitochondrial reagents.
2 context sentences(design, population, supporting numbers)
Rats were exercised for 10 consecutive days, after which isolated hearts were exposed to ischaemia/reperfusion (25 min/120 min).
Subsets of animals were exercised immediately after treatment with either NADPH-oxidase inhibitors apocynin or Vas2870, or with mitoTEMPO or Bendavia, which reduce mitochondrial reactive oxygen species levels.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).