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Study · Animal study (in vivo) · mouse · 2013

5 results

Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala.

Parker JA, McCullough KA, Field BC, Minnion JS, Martin NM, Ghatei MA, Bloom SR

International journal of obesity (2005)22 Jan 2013Cited by 83 (Europe PMC)

PMID23337772 (opens in a new tab)DOI10.1038/ijo.2012.227 (opens in a new tab)PepBankPUB-23337772
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, peripheral glucagon decreased food intake.

    In plain wordsIn mice, glucagon decreased food intake.

    Peptide
    Glucagon
    Outcome
    DecreaseFood intake
    Study

    mousen: not reported in source

    mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    Peripherally administered GLP-1 and glucagon decreased food intake and increased c-fos expression in the brainstem and amygdala.
    1 context sentence
    Summary · context
    To investigate the effects of peripherally administered GLP-1 and glucagon on food intake, neuronal activation and blood glucose in mice when administered individually and in combination.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, peripheral glucagon increased brainstem c-fos expression.

    In plain wordsIn mice, glucagon increased a marker of nerve-cell activation in the brainstem.

    Peptide
    Glucagon
    Outcome
    IncreaseBrainstem c-fos expression
    Study

    mousen: not reported in source

    mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    Peripherally administered GLP-1 and glucagon decreased food intake and increased c-fos expression in the brainstem and amygdala.
    1 context sentence
    Summary · context
    To investigate the effects of peripherally administered GLP-1 and glucagon on food intake, neuronal activation and blood glucose in mice when administered individually and in combination.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, peripheral glucagon increased amygdala c-fos expression.

    In plain wordsIn mice, glucagon increased a marker of nerve-cell activation in the amygdala.

    Peptide
    Glucagon
    Outcome
    IncreaseAmygdala c-fos expression
    Study

    mousen: not reported in source

    mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    Peripherally administered GLP-1 and glucagon decreased food intake and increased c-fos expression in the brainstem and amygdala.
    1 context sentence
    Summary · context
    To investigate the effects of peripherally administered GLP-1 and glucagon on food intake, neuronal activation and blood glucose in mice when administered individually and in combination.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, glucagon doses used for combined administration did not significantly affect feeding when given individually.

    In plain wordsIn mice, glucagon alone did not significantly change feeding at the doses used for the combination.

    Peptide
    Glucagon
    Outcome
    No significant changeFood intake at low doses
    Study

    mousen: not reported in source

    mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    Doses of GLP-1 and glucagon that individually did not significantly affect feeding
    1 context sentence
    Summary · context
    To investigate the effects of peripherally administered GLP-1 and glucagon on food intake, neuronal activation and blood glucose in mice when administered individually and in combination.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, glucagon alone had an acute hyperglycemic effect.

    In plain wordsIn mice, glucagon alone acutely increased blood glucose.

    Peptide
    Glucagon
    Outcome
    IncreaseAcute hyperglycemia
    Study

    mousen: not reported in source

    mice
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated · peripheralAs given in this study (mouse).

    Source sentences

    Summary
    Combined administration of GLP-1 and glucagon prevented the acute hyperglycemic effect of glucagon alone.
    1 context sentence
    Summary · context
    To investigate the effects of peripherally administered GLP-1 and glucagon on food intake, neuronal activation and blood glucose in mice when administered individually and in combination.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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