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Study · Animal study (in vivo) · mouse · 2013

8 results

Thymosin β4 protects C57BL/6 mice from bleomycin-induced damage in the lung.

Conte E, Genovese T, Gili E, Esposito E, Iemmolo M, Fruciano M, Fagone E, Pistorio MP, Crimi N, Cuzzocrea S, Vancheri C

European journal of clinical investigation16 Jan 2013Cited by 28 (Europe PMC)

PMID23320620 (opens in a new tab)DOI10.1111/eci.12048 (opens in a new tab)PepBankPUB-23320620
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice given bleomycin, Tβ4 treatment reduced weight loss compared with bleomycin alone.

    In plain wordsIn mice with lung damage, Tβ4 treatment led to less weight loss than damage alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseBody weight loss after bleomycin
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Comparator
    Bleomycin alone
    Outcome group
    Body weight · Respiratory
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    BLEO-treated mice who received Tβ4 did not lose as much weight and had a higher survival rate.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice given bleomycin, Tβ4 treatment gave a higher survival rate than bleomycin alone.

    In plain wordsIn mice with lung damage, more mice survived with Tβ4 treatment than with damage alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSurvival after bleomycin
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Comparator
    Bleomycin alone
    Outcome group
    Mortality · Whole body
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    had a higher survival rate.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice given bleomycin, Tβ4 treatment significantly reduced lung oedema compared with bleomycin alone.

    In plain wordsIn mice with lung damage, Tβ4 treatment reduced lung swelling compared with damage alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLung oedema
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Comparator
    Bleomycin alone
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, BLEO-induced inflammation and lung damage were substantially reduced by Tβ4 treatment, as demonstrated by the significant reduction in oedema, total collagen content, lung infiltration by leucocytes, MPO activity in lung homogenates, and histological evidence of the ongoing lung fibrosis.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice given bleomycin, Tβ4 treatment significantly reduced total lung collagen content compared with bleomycin alone.

    In plain wordsIn mice with lung damage, Tβ4 treatment reduced collagen in the lung compared with damage alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTotal lung collagen content
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Comparator
    Bleomycin alone
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, BLEO-induced inflammation and lung damage were substantially reduced by Tβ4 treatment, as demonstrated by the significant reduction in oedema, total collagen content, lung infiltration by leucocytes, MPO activity in lung homogenates, and histological evidence of the ongoing lung fibrosis.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice given bleomycin, Tβ4 treatment significantly reduced lung infiltration by leucocytes compared with bleomycin alone.

    In plain wordsIn mice with lung damage, Tβ4 treatment reduced white blood cells in the lung compared with damage alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLung infiltration by leucocytes
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Comparator
    Bleomycin alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, BLEO-induced inflammation and lung damage were substantially reduced by Tβ4 treatment, as demonstrated by the significant reduction in oedema, total collagen content, lung infiltration by leucocytes, MPO activity in lung homogenates, and histological evidence of the ongoing lung fibrosis.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice given bleomycin, Tβ4 treatment significantly reduced myeloperoxidase activity in lung homogenates compared with bleomycin alone.

    In plain wordsIn mice with lung damage, Tβ4 treatment lowered an enzyme marker of lung inflammation compared with damage alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLung myeloperoxidase activity
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Comparator
    Bleomycin alone
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, BLEO-induced inflammation and lung damage were substantially reduced by Tβ4 treatment, as demonstrated by the significant reduction in oedema, total collagen content, lung infiltration by leucocytes, MPO activity in lung homogenates, and histological evidence of the ongoing lung fibrosis.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In C57BL/6 mice given bleomycin, Tβ4 treatment reduced histological evidence of ongoing lung fibrosis compared with bleomycin alone.

    In plain wordsIn mice with lung damage, Tβ4 treatment reduced signs of lung scarring under the microscope compared with damage alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseHistological lung fibrosis
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Comparator
    Bleomycin alone
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Moreover, BLEO-induced inflammation and lung damage were substantially reduced by Tβ4 treatment, as demonstrated by the significant reduction in oedema, total collagen content, lung infiltration by leucocytes, MPO activity in lung homogenates, and histological evidence of the ongoing lung fibrosis.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).
  8. 08AnimalAnimal study (in vivo)Pharmacokinetics

    In C57BL/6 mice, immunohistochemistry showed strong Tβ4 reactivity in lung tissue of Tβ4-treated mice.

    In plain wordsIn mice, lung tissue of Tβ4-treated animals showed strong Tβ4 staining.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4 immunoreactivity in lung tissue
    Study

    mousen: not reported in source

    C57BL/6 mice with bleomycin-induced lung damage
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    6 mg/kg · intraperitoneal · day of bleomycin treatment and two additional doses; analysis after 1 weekAs given in this study (mouse).

    Source sentences

    Summary
    Results of IHC show a strong reactivity for Tβ4 in the lung tissue of Tβ4-treated mice.
    1 context sentence
    Summary · context
    C57BL/6 mice were treated with bleomycin (BLEO, 1 mg/kg) in the absence or presence of Tβ4 (6 mg/kg delivered intraperitoneally on the day of BLEO treatment and for two additional doses).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

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