Neuroprotective Peptide humanin inhibits inflammatory response in astrocytes induced by lipopolysaccharide.

Zhao ST, Zhao L, Li JH

Neurochemical research1 Jan 2013Cited by 48 (Europe PMC)

PMID23277413DOI10.1007/s11064-012-0951-6PepBankPUB-23277413

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In LPS-stimulated astrocytes, pretreatment with humanin significantly inhibited astrocyte overactivation in a concentration-dependent manner.
In plain wordsIn astrocyte cells, humanin pretreatment reduced the overactivation caused by LPS, and more humanin gave a larger effect.
Peptide
Humanin
Outcome
DecreaseAstrocyte overactivation after LPS
Study
n: not reported in source
Astrocytes with LPS-induced inflammation
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5, 10, 20 μMAs given in this study.
Source sentences
Summary
Pretreatment with HN (5, 10, 20 μM) led to a significant inhibition in astrocyte overactivation in a concentration dependent manner.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we used lipopolysaccharide (LPS) to induce astrocyte inflammation response.
Report a problemFND-2327741301
02LabIn vitro (cells)Efficacy outcome
In LPS-stimulated astrocytes, humanin pretreatment decreased interleukin-6 levels.
In plain wordsIn astrocyte cells, humanin pretreatment lowered IL-6 caused by LPS.
Peptide
Humanin
Outcome
DecreaseIL-6 level after LPS
Study
n: not reported in source
Astrocytes with LPS-induced inflammation
Comparator
LPS alone
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
5, 10, 20 μMAs given in this study.
Source sentences
Summary
We also found pretreatment with HN decreased the level of proinflammatory cytokines, interleukin (IL)-6, IL-1β and tumor necrosis factor α (TNFα) induced by LPS.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we used lipopolysaccharide (LPS) to induce astrocyte inflammation response.
Report a problemFND-2327741302
03LabIn vitro (cells)Efficacy outcome
In LPS-stimulated astrocytes, humanin pretreatment decreased interleukin-1β levels.
In plain wordsIn astrocyte cells, humanin pretreatment lowered IL-1β caused by LPS.
Peptide
Humanin
Outcome
DecreaseIL-1β level after LPS
Study
n: not reported in source
Astrocytes with LPS-induced inflammation
Comparator
LPS alone
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
5, 10, 20 μMAs given in this study.
Source sentences
Summary
We also found pretreatment with HN decreased the level of proinflammatory cytokines, interleukin (IL)-6, IL-1β and tumor necrosis factor α (TNFα) induced by LPS.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we used lipopolysaccharide (LPS) to induce astrocyte inflammation response.
Report a problemFND-2327741303
04LabIn vitro (cells)Efficacy outcome
In LPS-stimulated astrocytes, humanin pretreatment decreased tumor necrosis factor α levels.
In plain wordsIn astrocyte cells, humanin pretreatment lowered TNFα caused by LPS.
Peptide
Humanin
Outcome
DecreaseTNFα level after LPS
Study
n: not reported in source
Astrocytes with LPS-induced inflammation
Comparator
LPS alone
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
5, 10, 20 μMAs given in this study.
Source sentences
Summary
We also found pretreatment with HN decreased the level of proinflammatory cytokines, interleukin (IL)-6, IL-1β and tumor necrosis factor α (TNFα) induced by LPS.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we used lipopolysaccharide (LPS) to induce astrocyte inflammation response.
Report a problemFND-2327741304
05LabIn vitro (cells)Efficacy outcome
In LPS-stimulated astrocytes, humanin did not completely reverse the inflammatory injury.
In plain wordsIn astrocyte cells, humanin did not fully undo the inflammatory injury caused by LPS.
Peptide
Humanin
Outcome
MixedReversal of LPS inflammatory injury
Study
n: not reported in source
Astrocytes with LPS-induced inflammation
Comparator
LPS alone
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5, 10, 20 μMAs given in this study.
Source sentences
Summary
Furthermore, we noticed HN couldn't completely reverse the above inflammatory injury.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we used lipopolysaccharide (LPS) to induce astrocyte inflammation response.
Report a problemFND-2327741305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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