In frogs, transplanting larval limb progenitor cells with Wnt/β-catenin activation plus Sonic hedgehog, FGF10 and thymosin β4 allowed multidigit regenerates.
In plain wordsIn frogs, transplanted limb cells treated with several factors, including thymosin β4, let limbs regrow with several digits. Thymosin β4 alone was not tested.
- Peptide
- Thymosin beta-4 (human)
- Outcome
- IncreaseMultidigit limb regenerate formation
- Study
Xenopus frogn: not reported in source
limb regeneration after progenitor cell transplantation- Outcome group
- Wound healing · Musculoskeletal
Source sentences
Here, we show that frog limbs can be caused to form multidigit regenerates after receiving transplants of larval limb progenitor cells. It is necessary to activate Wnt/β-catenin signaling in the cells and to add Sonic hedgehog, FGF10, and thymosin β4.
1 context sentence(design, population, supporting numbers)
The frog Xenopus can normally regenerate its limbs at early developmental stages but loses the ability during metamorphosis.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).