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Study · Not a test of the peptide alone · 2012

3 results

[[Gly14]-humanin protects against Aβ₃₁₋₃₅-induced impairment of spatial learning and memory in rats].

Yuan L, Han WN, Li SF, Liu XJ, Wu MN, Qi JS

Sheng li xue bao : [Acta physiologica Sinica]1 Dec 2012Cited by 4 (Europe PMC)

PMID23258324 (opens in a new tab)PepBankPUB-23258324
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats given intrahippocampal amyloid-β₃₁₋₃₅, pretreatment with HNG at 0.2 nmol and 2.0 nmol suppressed the increase in traveled distance.

    In plain wordsIn rats with an amyloid injection, a humanin derivative reduced the rise in swim distance to find a hidden platform.

    Peptide
    Humanin
    Outcome
    DecreaseTraveled distance to the hidden platform
    Study

    ratn: not reported in source

    Rats with intrahippocampal Aβ31-35 injection, Morris water maze
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    pretreatment with HNG (0.2 nmol and 2.0 nmol) suppressed Aβ₃₁₋₃₅-induced increase in the traveled distance and decrease in swimming distance percentage
    1 context sentence
    Summary · context
    The present study was aimed to observe the effects of intrahippocampal injection of Aβ₃₁₋₃₅ on the spatial learning and memory of rats by using Morris water maze technique, and explore the neuroprotective effects and possible mechanism of [Gly14]-humanin (HNG) against Aβ-induced deficits in learning behavior.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats given intrahippocampal amyloid-β₃₁₋₃₅, pretreatment with HNG at 0.2 nmol and 2.0 nmol suppressed the decrease in swimming distance percentage in the target quadrant.

    In plain wordsIn rats with an amyloid injection, a humanin derivative reduced the drop in swimming in the target area during the memory test.

    Peptide
    Humanin
    Outcome
    IncreaseDistance percentage in the target quadrant
    Study

    ratn: not reported in source

    Rats with intrahippocampal Aβ31-35 injection, Morris water maze
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    pretreatment with HNG (0.2 nmol and 2.0 nmol) suppressed Aβ₃₁₋₃₅-induced increase in the traveled distance and decrease in swimming distance percentage
    1 context sentence
    Summary · context
    The present study was aimed to observe the effects of intrahippocampal injection of Aβ₃₁₋₃₅ on the spatial learning and memory of rats by using Morris water maze technique, and explore the neuroprotective effects and possible mechanism of [Gly14]-humanin (HNG) against Aβ-induced deficits in learning behavior.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In rats given intrahippocampal amyloid-β₃₁₋₃₅, genistein, a tyrosine kinase inhibitor, almost completely blocked the protective effects of HNG.

    In plain wordsIn rats with an amyloid injection, a tyrosine kinase blocker almost completely stopped the protection from a humanin derivative.

    Peptide
    Humanin
    Outcome
    DecreaseEffect of genistein on HNG protection
    Study

    ratn: not reported in source

    Rats with intrahippocampal Aβ31-35 injection, Morris water maze
    Comparator
    HNG without genistein
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Application of Genistein (40 nmol), a specific tyrosine kinase inhibitor, almost completely blocked the antagonistic effects of HNG against Aβ₃₁₋₃₅.
    1 context sentence
    Summary · context
    The present study was aimed to observe the effects of intrahippocampal injection of Aβ₃₁₋₃₅ on the spatial learning and memory of rats by using Morris water maze technique, and explore the neuroprotective effects and possible mechanism of [Gly14]-humanin (HNG) against Aβ-induced deficits in learning behavior.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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