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Study · Not a test of the peptide alone · 2013

4 results

Interspecies modeling and prediction of human exenatide pharmacokinetics.

Chen T, Mager DE, Kagan L

Pharmaceutical research15 Nov 2012Cited by 30 (Europe PMC)

PMID23229855 (opens in a new tab)PMCIDPMC3732180 (opens in a new tab)DOI10.1007/s11095-012-0917-z (opens in a new tab)PepBankPUB-23229855
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

  1. 01Computer modelNot a test of Exenatide (exendin-4) aloneIn silicoPharmacokinetics

    In interspecies pharmacokinetic modeling, the exenatide model fit animal concentration data well and produced reasonable parameter estimates.

    In plain wordsComputer modeling of exenatide fit animal concentration data well and produced reasonable parameter estimates.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Not applicableModel fit to animal pharmacokinetics
    Study

    Mice, rats, monkeys and humansn: not reported in source

    Target-mediated drug disposition with allometric scaling
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The final model provided a good simultaneous fit to all animal data and reasonable parameter estimates.
    3 context sentences
    Summary · context
    A target-mediated drug disposition (TMDD) model was simultaneously fit to concentration-time profiles of exenatide over a wide range of intravenous (IV) and subcutaneous (SC) doses obtained from mice, rats, and monkeys.
    Summary · context
    Allometric relationships were incorporated into the model to scale parameters based on species body weight.
    Summary · context
    Human pharmacokinetic profiles following IV and SC administration were simulated using the final model structure and parameter estimates and compared to clinical data.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  2. 02Computer modelNot a test of Exenatide (exendin-4) aloneIn silicoPharmacokinetics

    In interspecies modeling, exenatide receptor binding affinity depended on species.

    In plain wordsComputer modeling indicated that exenatide receptor binding affinity differed by species.

    Peptide
    Exenatide (exendin-4)
    Outcome
    MixedReceptor binding affinity across species
    Study

    Mice, rats, monkeys and humansn: not reported in source

    Target-mediated drug disposition with allometric scaling
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Exenatide receptor binding affinity and baseline receptor concentrations were species-dependent.
    3 context sentences
    Summary · context
    A target-mediated drug disposition (TMDD) model was simultaneously fit to concentration-time profiles of exenatide over a wide range of intravenous (IV) and subcutaneous (SC) doses obtained from mice, rats, and monkeys.
    Summary · context
    Allometric relationships were incorporated into the model to scale parameters based on species body weight.
    Summary · context
    Human pharmacokinetic profiles following IV and SC administration were simulated using the final model structure and parameter estimates and compared to clinical data.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  3. 03Computer modelNot a test of Exenatide (exendin-4) aloneIn silicoPharmacokinetics

    In interspecies exenatide modeling, baseline receptor concentrations depended on species.

    In plain wordsComputer modeling of exenatide indicated that baseline receptor concentrations differed by species.

    Peptide
    Exenatide (exendin-4)
    Outcome
    MixedBaseline receptor concentrations across species
    Study

    Mice, rats, monkeys and humansn: not reported in source

    Target-mediated drug disposition with allometric scaling
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Exenatide receptor binding affinity and baseline receptor concentrations were species-dependent.
    3 context sentences
    Summary · context
    A target-mediated drug disposition (TMDD) model was simultaneously fit to concentration-time profiles of exenatide over a wide range of intravenous (IV) and subcutaneous (SC) doses obtained from mice, rats, and monkeys.
    Summary · context
    Allometric relationships were incorporated into the model to scale parameters based on species body weight.
    Summary · context
    Human pharmacokinetic profiles following IV and SC administration were simulated using the final model structure and parameter estimates and compared to clinical data.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

  4. 04Computer modelNot a test of Exenatide (exendin-4) aloneIn silicoPharmacokinetics

    In exenatide modeling, rat absorption parameters best predicted human subcutaneous absorption, while allometric scaling also produced good predictions.

    In plain wordsComputer modeling best predicted human exenatide absorption with rat parameters, while scaling preclinical parameters also gave good predictions.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Not applicablePrediction of human subcutaneous absorption
    Study

    Mice, rats, monkeys and humansn: not reported in source

    Target-mediated drug disposition with allometric scaling
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Absorption parameters from rat provided the best prediction of exenatide SC absorption in humans, but good predictions could also be obtained using allometric scaling of preclinical absorption parameters.
    3 context sentences
    Summary · context
    A target-mediated drug disposition (TMDD) model was simultaneously fit to concentration-time profiles of exenatide over a wide range of intravenous (IV) and subcutaneous (SC) doses obtained from mice, rats, and monkeys.
    Summary · context
    Allometric relationships were incorporated into the model to scale parameters based on species body weight.
    Summary · context
    Human pharmacokinetic profiles following IV and SC administration were simulated using the final model structure and parameter estimates and compared to clinical data.

    In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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