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Study · Animal study (in vivo) · mouse · 2013

6 results

Effect of a gonadotropin-releasing hormone analogue on cyclophosphamide-induced ovarian toxicity in adult mice.

Kishk EA, Mohammed Ali MH

Archives of gynecology and obstetrics7 Dec 2012Cited by 19 (Europe PMC)

PMID23224696 (opens in a new tab)DOI10.1007/s00404-012-2658-y (opens in a new tab)PepBankPUB-23224696
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female mice, low-dose triptorelin increased primordial follicles versus cyclophosphamide alone.

    In plain wordsIn mice, low-dose triptorelin increased primordial follicles compared with cyclophosphamide alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePrimordial follicles
    Study

    mousen = 12

    cyclophosphamide-induced ovarian toxicity
    Comparator
    cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.8 mg/kg · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In the TL + CPA group, there was a significant increase in primordial, primary, secondary and antral follicles compared with the CPA group (p < 0.05), showing the effect of triptorelin on ovarian protection.
    2 context sentences
    Summary · context
    Mice in both the TL + CPA and the TH + CPA groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively.
    Summary · context
    Four weeks later, mice in the CPA, TL + CPA and TH + CPA groups were injected with cyclophosphamide, intraperitoneally, at a dose of 50 mg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female mice, low-dose triptorelin increased primary follicles versus cyclophosphamide alone.

    In plain wordsIn mice, low-dose triptorelin increased primary follicles compared with cyclophosphamide alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePrimary follicles
    Study

    mousen = 12

    cyclophosphamide-induced ovarian toxicity
    Comparator
    cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.8 mg/kg · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In the TL + CPA group, there was a significant increase in primordial, primary, secondary and antral follicles compared with the CPA group (p < 0.05), showing the effect of triptorelin on ovarian protection.
    2 context sentences
    Summary · context
    Mice in both the TL + CPA and the TH + CPA groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively.
    Summary · context
    Four weeks later, mice in the CPA, TL + CPA and TH + CPA groups were injected with cyclophosphamide, intraperitoneally, at a dose of 50 mg/kg.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female mice, low-dose triptorelin increased secondary follicles versus cyclophosphamide alone.

    In plain wordsIn mice, low-dose triptorelin increased secondary follicles compared with cyclophosphamide alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseSecondary follicles
    Study

    mousen = 12

    cyclophosphamide-induced ovarian toxicity
    Comparator
    cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.8 mg/kg · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In the TL + CPA group, there was a significant increase in primordial, primary, secondary and antral follicles compared with the CPA group (p < 0.05), showing the effect of triptorelin on ovarian protection.
    2 context sentences
    Summary · context
    Mice in both the TL + CPA and the TH + CPA groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively.
    Summary · context
    Four weeks later, mice in the CPA, TL + CPA and TH + CPA groups were injected with cyclophosphamide, intraperitoneally, at a dose of 50 mg/kg.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female mice, low-dose triptorelin increased antral follicles versus cyclophosphamide alone.

    In plain wordsIn mice, low-dose triptorelin increased antral follicles compared with cyclophosphamide alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseAntral follicles
    Study

    mousen = 12

    cyclophosphamide-induced ovarian toxicity
    Comparator
    cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.8 mg/kg · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    In the TL + CPA group, there was a significant increase in primordial, primary, secondary and antral follicles compared with the CPA group (p < 0.05), showing the effect of triptorelin on ovarian protection.
    2 context sentences
    Summary · context
    Mice in both the TL + CPA and the TH + CPA groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively.
    Summary · context
    Four weeks later, mice in the CPA, TL + CPA and TH + CPA groups were injected with cyclophosphamide, intraperitoneally, at a dose of 50 mg/kg.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female mice, high-dose triptorelin increased primordial follicles versus cyclophosphamide alone.

    In plain wordsIn mice, high-dose triptorelin increased primordial follicles compared with cyclophosphamide alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePrimordial follicles
    Study

    mousen = 12

    cyclophosphamide-induced ovarian toxicity
    Comparator
    cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    38 mg/kg · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Regarding, the high-dose GnRH agonist the difference was statistically highly significant for primordial and primary follicles (p < 0.001).
    3 context sentences
    Summary · context
    In the TL + CPA group, there was a significant increase in primordial, primary, secondary and antral follicles compared with the CPA group (p < 0.05), showing the effect of triptorelin on ovarian protection.
    Summary · context
    Mice in both the TL + CPA and the TH + CPA groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively.
    Summary · context
    Four weeks later, mice in the CPA, TL + CPA and TH + CPA groups were injected with cyclophosphamide, intraperitoneally, at a dose of 50 mg/kg.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In female mice, high-dose triptorelin increased primary follicles versus cyclophosphamide alone.

    In plain wordsIn mice, high-dose triptorelin increased primary follicles compared with cyclophosphamide alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreasePrimary follicles
    Study

    mousen = 12

    cyclophosphamide-induced ovarian toxicity
    Comparator
    cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    38 mg/kg · subcutaneousAs given in this study (mouse).

    Source sentences

    Summary
    Regarding, the high-dose GnRH agonist the difference was statistically highly significant for primordial and primary follicles (p < 0.001).
    3 context sentences
    Summary · context
    In the TL + CPA group, there was a significant increase in primordial, primary, secondary and antral follicles compared with the CPA group (p < 0.05), showing the effect of triptorelin on ovarian protection.
    Summary · context
    Mice in both the TL + CPA and the TH + CPA groups were injected with 3.8 and 38 mg/kg of triptorelin subcutaneously, respectively.
    Summary · context
    Four weeks later, mice in the CPA, TL + CPA and TH + CPA groups were injected with cyclophosphamide, intraperitoneally, at a dose of 50 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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