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Study · Measured the body's own peptide · 2013

6 results

Circulating humanin levels are associated with preserved coronary endothelial function.

Widmer RJ, Flammer AJ, Herrmann J, Rodriguez-Porcel M, Wan J, Cohen P, Lerman LO, Lerman A

American journal of physiology. Heart and circulatory physiology7 Dec 2012Cited by 109 (Europe PMC)

PMID23220334 (opens in a new tab)PMCIDPMC3774506 (opens in a new tab)DOI10.1152/ajpheart.00765.2012 (opens in a new tab)PepBankPUB-23220334
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients undergoing coronary angiography, those with coronary endothelial dysfunction had significantly lower plasma humanin levels than those with normal endothelial function.

    In plain wordsIn people having coronary tests, the body's own humanin levels were lower in those with poor coronary vessel function.

    Peptide
    Humanin
    Outcome
    DecreasePlasma humanin level by coronary endothelial function
    Study

    n = 40

    Comparator
    Patients with normal coronary endothelial function
    Outcome group
    Lung injury and fibrosis · Cardiovascular

    Measurements

    Humanin level
    1.3 ng/ml
    endothelial dysfunction
    Humanin level
    2.2 ng/ml
    normal endothelial function

    Source sentences

    Summary
    Patients with coronary endothelial dysfunction (change in CBF = -33 ± 25%) had significantly lower humanin levels (1.3 ± 1.1 vs. 2.2 ± 1.5 ng/ml, P = 0.03) compared with those with normal coronary endothelial function (change in CBF = 194 ± 157%).
    1 context sentence
    Summary · context
    Forty patients undergoing coronary angiography and endothelial function testing were included and subsequently divided into two groups based on coronary blood flow (CBF) response to intracoronary acetylcholine (normal ≥ 50% increase from baseline, n = 20 each).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients undergoing coronary angiography, plasma humanin levels correlated positively with the improvement in coronary blood flow.

    In plain wordsIn people having coronary tests, higher natural humanin levels were linked to a better coronary blood flow response.

    Peptide
    Humanin
    Outcome
    IncreaseCorrelation of humanin level with coronary blood flow response
    Study

    n = 40

    Outcome group
    Lung injury and fibrosis · Cardiovascular

    Source sentences

    Summary
    There was a significant and positive correlation between improved CBF and humanin levels (P = 0.0091)
    1 context sentence
    Summary · context
    Forty patients undergoing coronary angiography and endothelial function testing were included and subsequently divided into two groups based on coronary blood flow (CBF) response to intracoronary acetylcholine (normal ≥ 50% increase from baseline, n = 20 each).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients undergoing coronary angiography, plasma humanin levels did not correlate with changes in coronary flow reserve.

    In plain wordsIn people having coronary tests, the body's own humanin levels were not linked to changes in coronary flow reserve.

    Peptide
    Humanin
    Outcome
    No significant changeCorrelation of humanin level with coronary flow reserve
    Study

    n = 40

    Outcome group
    Lung injury and fibrosis · Cardiovascular

    Source sentences

    Summary
    not seen with changes in coronary flow reserve (P = 0.76).
    1 context sentence
    Summary · context
    Forty patients undergoing coronary angiography and endothelial function testing were included and subsequently divided into two groups based on coronary blood flow (CBF) response to intracoronary acetylcholine (normal ≥ 50% increase from baseline, n = 20 each).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In patients undergoing coronary angiography, C-reactive protein was not associated with plasma humanin levels.

    In plain wordsIn people having coronary tests, C-reactive protein was not linked to the body's own humanin levels.

    Peptide
    Humanin
    Outcome
    No significant changeAssociation of C-reactive protein with humanin level
    Study

    n = 40

    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    C-reactive protein, Lp-Pla(2), and homocysteine were not associated with humanin levels.
    1 context sentence
    Summary · context
    Forty patients undergoing coronary angiography and endothelial function testing were included and subsequently divided into two groups based on coronary blood flow (CBF) response to intracoronary acetylcholine (normal ≥ 50% increase from baseline, n = 20 each).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In patients undergoing coronary angiography, Lp-Pla(2) was not associated with plasma humanin levels.

    In plain wordsIn people having coronary tests, Lp-Pla(2) was not linked to the body's own humanin levels.

    Peptide
    Humanin
    Outcome
    No significant changeAssociation of Lp-Pla(2) with humanin level
    Study

    n = 40

    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    C-reactive protein, Lp-Pla(2), and homocysteine were not associated with humanin levels.
    1 context sentence
    Summary · context
    Forty patients undergoing coronary angiography and endothelial function testing were included and subsequently divided into two groups based on coronary blood flow (CBF) response to intracoronary acetylcholine (normal ≥ 50% increase from baseline, n = 20 each).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In patients undergoing coronary angiography, homocysteine was not associated with plasma humanin levels.

    In plain wordsIn people having coronary tests, homocysteine was not linked to the body's own humanin levels.

    Peptide
    Humanin
    Outcome
    No significant changeAssociation of homocysteine with humanin level
    Study

    n = 40

    Outcome group
    Cardiometabolic risk factors · Cardiovascular

    Source sentences

    Summary
    C-reactive protein, Lp-Pla(2), and homocysteine were not associated with humanin levels.
    1 context sentence
    Summary · context
    Forty patients undergoing coronary angiography and endothelial function testing were included and subsequently divided into two groups based on coronary blood flow (CBF) response to intracoronary acetylcholine (normal ≥ 50% increase from baseline, n = 20 each).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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