The glucagon-like peptide 1 analogue Exendin-4 attenuates alcohol mediated behaviors in rodents.

Egecioglu E, Steensland P, Fredriksson I, Feltmann K, Engel JA, Jerlhag E

Psychoneuroendocrinology7 Dec 2012Cited by 179 (Europe PMC)

PMID23219472DOI10.1016/j.psyneuen.2012.11.009PepBankPUB-23219472

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice, Ex4 attenuated alcohol-induced locomotor stimulation at a dose without an effect by itself.
In plain wordsIn mice, Ex4 reduced alcohol-induced movement stimulation.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseAlcohol-induced locomotor stimulation
Study
mousen: not reported in source
Alcohol-induced reward
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Treatment with Ex4, at a dose with no effect per se, attenuated alcohol-induced locomotor stimulation and accumbal dopamine release in mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on various measures of alcohol-induced reward as well as on alcohol intake and alcohol seeking behavior in rodents.
Report a problemFND-2321947201
02AnimalAnimal study (in vivo)Mechanism
In mice, Ex4 attenuated alcohol-induced accumbal dopamine release at a dose without an effect by itself.
In plain wordsIn mice, Ex4 reduced alcohol-induced dopamine release in the nucleus accumbens.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseAccumbal dopamine release
Study
mousen: not reported in source
Alcohol-induced reward
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Treatment with Ex4, at a dose with no effect per se, attenuated alcohol-induced locomotor stimulation and accumbal dopamine release in mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on various measures of alcohol-induced reward as well as on alcohol intake and alcohol seeking behavior in rodents.
Report a problemFND-2321947202
03AnimalAnimal study (in vivo)Efficacy outcome
In mice, acute Ex4 abolished conditioned place preference for alcohol.
In plain wordsIn mice, acute Ex4 abolished conditioned preference for a place associated with alcohol.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseAlcohol conditioned place preference after acute treatment
Study
mousen: not reported in source
Alcohol-induced reward
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
Dose not stated · Acute treatmentAs given in this study (mouse).
Source sentences
Summary
Furthermore, conditioned place preference for alcohol was abolished by both acute and chronic treatment with Ex4 in mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on various measures of alcohol-induced reward as well as on alcohol intake and alcohol seeking behavior in rodents.
Report a problemFND-2321947203
04AnimalAnimal study (in vivo)Efficacy outcome
In mice, chronic Ex4 abolished conditioned place preference for alcohol.
In plain wordsIn mice, chronic Ex4 abolished conditioned preference for a place associated with alcohol.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseAlcohol conditioned place preference after chronic treatment
Study
mousen: not reported in source
Alcohol-induced reward
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
Dose not stated · Chronic treatmentAs given in this study (mouse).
Source sentences
Summary
Furthermore, conditioned place preference for alcohol was abolished by both acute and chronic treatment with Ex4 in mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on various measures of alcohol-induced reward as well as on alcohol intake and alcohol seeking behavior in rodents.
Report a problemFND-2321947204
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, Ex4 decreased alcohol intake in the intermittent access two-bottle-choice model.
In plain wordsIn rats, Ex4 reduced alcohol intake in a two-bottle-choice test.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseAlcohol intake
Study
ratn: not reported in source
Intermittent access 20% alcohol two-bottle-choice model
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Finally we found that Ex4 treatment decreased alcohol intake, using the intermittent access 20% alcohol two-bottle-choice model, as well as alcohol seeking behavior, using the progressive ratio test in the operant self-administration model, in rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on various measures of alcohol-induced reward as well as on alcohol intake and alcohol seeking behavior in rodents.
Report a problemFND-2321947205
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, Ex4 decreased alcohol seeking in the progressive ratio test.
In plain wordsIn rats, Ex4 reduced alcohol seeking in an operant test.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseAlcohol seeking
Study
ratn: not reported in source
Progressive ratio operant self-administration model
Outcome group
Addiction, withdrawal and alcohol intake · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Finally we found that Ex4 treatment decreased alcohol intake, using the intermittent access 20% alcohol two-bottle-choice model, as well as alcohol seeking behavior, using the progressive ratio test in the operant self-administration model, in rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein we investigated the effects of the GLP-1 receptor agonist, Exendin-4 (Ex4), on various measures of alcohol-induced reward as well as on alcohol intake and alcohol seeking behavior in rodents.
Report a problemFND-2321947206

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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