[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice.

Wang T, Zhang L, Zhang M, Bao H, Liu W, Wang Y, Wang L, Dai D, Chang P, Dong W, Chen X, Tao L

Neuroscience20 Nov 2012Cited by 17 (Europe PMC)

PMID23178909DOI10.1016/j.neuroscience.2012.11.019PepBankPUB-23178909

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

14 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice with TBI, HNG given intracerebroventricularly before injury decreased the number of cells with plasmalemma permeability in the injured cortex and hippocampus at 48 h.
In plain wordsIn mice with brain injury, HNG given before the injury reduced the number of damaged cells in the injured brain areas.
Peptide
Humanin
Outcome
DecreaseCells with plasmalemma permeability in injured cortex and hippocampus
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Compared to vehicle-treated groups, mice administered HNG intracerebroventricularly (i.c.v.) prior to TBI had decreased cells with plasmalemma permeability in the injured cortex and hippocampus (48 h, P<0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890901
02AnimalAnimal study (in vivo)Efficacy outcome
In mice with TBI, HNG given intracerebroventricularly before injury reduced brain lesion volume on days 14 and 28.
In plain wordsIn mice with brain injury, HNG given before the injury shrank the brain damage area compared with vehicle.
Peptide
Humanin
Outcome
DecreaseBrain lesion volume (i.c.v. HNG)
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Compared to vehicle-treated groups, mice administered HNG intracerebroventricularly (i.c.v.) prior to TBI had decreased cells with plasmalemma permeability in the injured cortex and hippocampus (48 h, P<0.01), reduced brain lesion volume (days 14 and 28, P<0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890902
03AnimalAnimal study (in vivo)Efficacy outcome
In mice with TBI, HNG given intracerebroventricularly before injury improved motor performance on days 1-4.
In plain wordsIn mice with brain injury, HNG given before the injury improved movement ability compared with vehicle.
Peptide
Humanin
Outcome
IncreaseMotor performance (i.c.v. HNG)
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Compared to vehicle-treated groups, mice administered HNG intracerebroventricularly (i.c.v.) prior to TBI had decreased cells with plasmalemma permeability in the injured cortex and hippocampus (48 h, P<0.01), reduced brain lesion volume (days 14 and 28, P<0.05), improved motor performance (days 1-4, P<0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890903
04AnimalAnimal study (in vivo)Efficacy outcome
In mice with TBI, HNG given intracerebroventricularly before injury ameliorated performance in the Morris water maze test on days 11-13.
In plain wordsIn mice with brain injury, HNG given before the injury improved maze learning compared with vehicle.
Peptide
Humanin
Outcome
IncreaseMorris water maze performance (i.c.v. HNG)
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Compared to vehicle-treated groups, mice administered HNG intracerebroventricularly (i.c.v.) prior to TBI had decreased cells with plasmalemma permeability in the injured cortex and hippocampus (48 h, P<0.01), reduced brain lesion volume (days 14 and 28, P<0.05), improved motor performance (days 1-4…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890904
05AnimalAnimal study (in vivo)Efficacy outcome
In mice with TBI, HNG given intraperitoneally 1 h and 2 h after injury also reduced lesion volume at day 14.
In plain wordsIn mice with brain injury, HNG given after the injury also shrank the brain damage area.
Peptide
Humanin
Outcome
DecreaseBrain lesion volume (i.p. HNG after TBI)
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Reduced lesion volume (day 14, P<0.05) was also observed even when HNG was administered intraperitoneally (i.p.) at 1h and 2h post TBI, and minor amelioration in motor and Morris water maze test deficits was also observed.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890905
06AnimalAnimal study (in vivo)Efficacy outcome
In mice with TBI, HNG given intraperitoneally after injury produced minor amelioration of motor deficits.
In plain wordsIn mice with brain injury, HNG given after the injury gave a small improvement in movement problems.
Peptide
Humanin
Outcome
DecreaseMotor deficits (i.p. HNG after TBI)
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Reduced lesion volume (day 14, P<0.05) was also observed even when HNG was administered intraperitoneally (i.p.) at 1h and 2h post TBI, and minor amelioration in motor and Morris water maze test deficits was also observed.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890906
07AnimalAnimal study (in vivo)Efficacy outcome
In mice with TBI, HNG given intraperitoneally after injury produced minor amelioration of Morris water maze test deficits.
In plain wordsIn mice with brain injury, HNG given after the injury gave a small improvement in maze learning problems.
Peptide
Humanin
Outcome
DecreaseMorris water maze deficits (i.p. HNG after TBI)
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (mouse).
Source sentences
Summary
Reduced lesion volume (day 14, P<0.05) was also observed even when HNG was administered intraperitoneally (i.p.) at 1h and 2h post TBI, and minor amelioration in motor and Morris water maze test deficits was also observed.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890907
08AnimalAnimal study (in vivo)Mechanism
In mice with TBI, HNG pretreatment reversed TBI-induced cleavage of caspase-3 in the injured cortex and hippocampus.
In plain wordsIn mice with brain injury, HNG pretreatment reduced activation of a cell-death enzyme, caspase-3, in injured brain areas.
Peptide
Humanin
Outcome
DecreaseTBI-induced caspase-3 cleavage
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Immunoblotting results showed that HNG pretreatment (i.c.v.) reversed TBI-induced cleavage of cysteinyl aspartate-specific protease-3 and poly ADPribose-polymerase and decline of Bcl-2, suppressed LC3II, Beclin-1 and vacuolar sorting protein 34 activation and maintained p62 levels in the injured cor…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890908
09AnimalAnimal study (in vivo)Mechanism
In mice with TBI, HNG pretreatment reversed TBI-induced cleavage of poly ADP-ribose polymerase in the injured cortex and hippocampus.
In plain wordsIn mice with brain injury, HNG pretreatment reduced a cell-death marker, PARP cleavage, in injured brain areas.
Peptide
Humanin
Outcome
DecreaseTBI-induced PARP cleavage
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Immunoblotting results showed that HNG pretreatment (i.c.v.) reversed TBI-induced cleavage of cysteinyl aspartate-specific protease-3 and poly ADPribose-polymerase and decline of Bcl-2, suppressed LC3II, Beclin-1 and vacuolar sorting protein 34 activation and maintained p62 levels in the injured cor…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890909
10AnimalAnimal study (in vivo)Mechanism
In mice with TBI, HNG pretreatment reversed the TBI-induced decline of Bcl-2 in the injured cortex and hippocampus.
In plain wordsIn mice with brain injury, HNG pretreatment kept up levels of a cell-survival protein, Bcl-2, in injured brain areas.
Peptide
Humanin
Outcome
IncreaseBcl-2 level after TBI
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Immunoblotting results showed that HNG pretreatment (i.c.v.) reversed TBI-induced cleavage of cysteinyl aspartate-specific protease-3 and poly ADPribose-polymerase and decline of Bcl-2, suppressed LC3II, Beclin-1 and vacuolar sorting protein 34 activation and maintained p62 levels in the injured cor…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890910
11AnimalAnimal study (in vivo)Mechanism
In mice with TBI, HNG pretreatment suppressed LC3II activation in the injured cortex and hippocampus.
In plain wordsIn mice with brain injury, HNG pretreatment lowered a marker of cell self-digestion, LC3II, in injured brain areas.
Peptide
Humanin
Outcome
DecreaseLC3II activation after TBI
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Immunoblotting results showed that HNG pretreatment (i.c.v.) reversed TBI-induced cleavage of cysteinyl aspartate-specific protease-3 and poly ADPribose-polymerase and decline of Bcl-2, suppressed LC3II, Beclin-1 and vacuolar sorting protein 34 activation and maintained p62 levels in the injured cor…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890911
12AnimalAnimal study (in vivo)Mechanism
In mice with TBI, HNG pretreatment suppressed Beclin-1 activation in the injured cortex and hippocampus.
In plain wordsIn mice with brain injury, HNG pretreatment lowered a marker of cell self-digestion, Beclin-1, in injured brain areas.
Peptide
Humanin
Outcome
DecreaseBeclin-1 activation after TBI
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Immunoblotting results showed that HNG pretreatment (i.c.v.) reversed TBI-induced cleavage of cysteinyl aspartate-specific protease-3 and poly ADPribose-polymerase and decline of Bcl-2, suppressed LC3II, Beclin-1 and vacuolar sorting protein 34 activation and maintained p62 levels in the injured cor…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890912
13AnimalAnimal study (in vivo)Mechanism
In mice with TBI, HNG pretreatment suppressed vacuolar sorting protein 34 activation in the injured cortex and hippocampus.
In plain wordsIn mice with brain injury, HNG pretreatment lowered a marker of cell self-digestion, VPS34, in injured brain areas.
Peptide
Humanin
Outcome
DecreaseVacuolar sorting protein 34 activation after TBI
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Immunoblotting results showed that HNG pretreatment (i.c.v.) reversed TBI-induced cleavage of cysteinyl aspartate-specific protease-3 and poly ADPribose-polymerase and decline of Bcl-2, suppressed LC3II, Beclin-1 and vacuolar sorting protein 34 activation and maintained p62 levels in the injured cor…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890913
14AnimalAnimal study (in vivo)Mechanism
In mice with TBI, HNG pretreatment maintained p62 levels in the injured cortex and hippocampus.
In plain wordsIn mice with brain injury, HNG pretreatment kept levels of the p62 protein steady in injured brain areas.
Peptide
Humanin
Outcome
No significant changep62 levels after TBI
Study
mousen: not reported in source
traumatic brain injury (TBI)
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (mouse).
Source sentences
Summary
Immunoblotting results showed that HNG pretreatment (i.c.v.) reversed TBI-induced cleavage of cysteinyl aspartate-specific protease-3 and poly ADPribose-polymerase and decline of Bcl-2, suppressed LC3II, Beclin-1 and vacuolar sorting protein 34 activation and maintained p62 levels in the injured cor…
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we aimed to examine the neuroprotective effect of HNG on traumatic brain injury (TBI) in mice and explored whether the protective effect was associated with regulating apoptosis and autophagy.
Report a problemFND-2317890914

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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