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Study · In vitro (cells) · 2013

8 results

Thymosin β4 reduces senescence of endothelial progenitor cells via the PI3K/Akt/eNOS signal transduction pathway.

Li J, Yu L, Zhao Y, Fu G, Zhou B

Molecular medicine reports12 Nov 2012Cited by 13 (Europe PMC)

PMID23151623 (opens in a new tab)DOI10.3892/mmr.2012.1180 (opens in a new tab)PepBankPUB-23151623
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human endothelial progenitor cells, Tβ4 inhibited senescence in a concentration-dependent manner.

    In plain wordsIn cells, Tβ4 reduced the ageing of endothelial progenitor cells, and more Tβ4 gave a larger effect.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseEPC senescence
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 inhibited EPC senescence in a concentration‑dependent manner.
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  2. 02LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 increased telomerase activity.

    In plain wordsIn cells, Tβ4 raised telomerase activity in endothelial progenitor cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTelomerase activity
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Tβ4 increased telomerase activity and expression of telomerase reverse transcriptase mRNA in EPCs.
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  3. 03LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 increased expression of telomerase reverse transcriptase mRNA.

    In plain wordsIn cells, Tβ4 raised the mRNA level of telomerase reverse transcriptase in endothelial progenitor cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTelomerase reverse transcriptase mRNA expression
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Tβ4 increased telomerase activity and expression of telomerase reverse transcriptase mRNA in EPCs.
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  4. 04LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 regulated the expression of p21. The abstract does not state the direction.

    In plain wordsIn cells, Tβ4 changed the level of p21 in endothelial progenitor cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedp21 expression
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 also regulated the expression of p21, p27 and cyclin D1.
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  5. 05LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 regulated the expression of p27. The abstract does not state the direction.

    In plain wordsIn cells, Tβ4 changed the level of p27 in endothelial progenitor cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedp27 expression
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 also regulated the expression of p21, p27 and cyclin D1.
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  6. 06LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, Tβ4 regulated the expression of cyclin D1. The abstract does not state the direction.

    In plain wordsIn cells, Tβ4 changed the level of cyclin D1 in endothelial progenitor cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedCyclin D1 expression
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 also regulated the expression of p21, p27 and cyclin D1.
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  7. 07LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, the PI3K inhibitor wortmannin eliminated the effect of Tβ4 on senescence.

    In plain wordsIn cells, blocking PI3K with wortmannin removed the effect of Tβ4 on cell ageing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeTβ4 effect on senescence with PI3K inhibitor wortmannin
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Comparator
    Tβ4 without inhibitor
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects of Tβ4 on EPC senescence were eliminated by the phosphoinositide 3'‑kinase (PI3K) inhibitor, wortmannin and the endothelial nitric oxide synthase inhibitor, L‑nitroarginine methyl ester hydrochloride (L‑NAME).
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.
  8. 08LabIn vitro (cells)Mechanism

    In human endothelial progenitor cells, the eNOS inhibitor L-NAME eliminated the effect of Tβ4 on senescence.

    In plain wordsIn cells, blocking eNOS with L-NAME removed the effect of Tβ4 on cell ageing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeTβ4 effect on senescence with eNOS inhibitor L-NAME
    Study

    humann: not reported in source

    circulating endothelial progenitor cells from healthy volunteers
    Comparator
    Tβ4 without inhibitor
    Outcome group
    Aging markers · Aging and longevity
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effects of Tβ4 on EPC senescence were eliminated by the phosphoinositide 3'‑kinase (PI3K) inhibitor, wortmannin and the endothelial nitric oxide synthase inhibitor, L‑nitroarginine methyl ester hydrochloride (L‑NAME).
    1 context sentence
    Summary · context
    Circulating EPCs isolated from healthy volunteers were cultured in the absence or presence of Tβ4 and various signal cascade inhibitors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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