Kisspeptin-10 induces dose dependent degeneration in prepubertal rat prostate gland.

Ramzan F, Qureshi IZ, Ramzan M, Ramzan MH, Ramzan F

The Prostate5 Nov 2012Cited by 6 (Europe PMC)

PMID23129449DOI10.1002/pros.22609PepBankPUB-23129449

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin at 1 µg twice daily for 12 days decreased prostate weight versus control.
In plain wordsIn young male rats, the highest kisspeptin dose lowered prostate weight compared with control.
Peptide
Kisspeptin-10
Outcome
DecreaseProstate weight
Study
ratn: not reported in source
Prepubertal male Sprague-Dawley rats (PND 35)
Comparator
Control
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
1 µg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Prostate weights decreased significantly (P < 0.05) at 1 µg treatment dose of kisspeptin.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this kisspeptin was administered as subchronic (12 days) twice daily i.p. dose at three different dosage regimens: 10 pg, 1 ng and 1 µg, to prepubertal male Sprague-Dawley rats (PND 35).
Report a problemFND-2312944901
02AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin decreased the epithelial height of prostate secretory acini at 10 pg, 1 ng and 1 µg doses versus control.
In plain wordsIn young male rats, kisspeptin lowered the height of prostate gland lining cells at all three doses compared with control.
Peptide
Kisspeptin-10
Outcome
DecreaseEpithelial height of prostate secretory acini
Study
ratn: not reported in source
Prepubertal male Sprague-Dawley rats (PND 35)
Comparator
Control
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
10 pg, 1 ng and 1 µg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
The epithelial height of secretory acini of prostate decreased at 10 pg (P < 0.05), 1 ng, and 1 µg doses (P < 0.001).
1 context sentence(design, population, supporting numbers)
Summary · context
To address this kisspeptin was administered as subchronic (12 days) twice daily i.p. dose at three different dosage regimens: 10 pg, 1 ng and 1 µg, to prepubertal male Sprague-Dawley rats (PND 35).
Report a problemFND-2312944902
03AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, kisspeptin treatment was followed by decreased epithelial cell height, epithelial folding and dilatation of organelles in the prostate.
In plain wordsIn young male rats, kisspeptin treatment was followed by changes in prostate cell structure.
Peptide
Kisspeptin-10
Outcome
Not applicableProstate histomorphology and ultrastructure
Study
ratn: not reported in source
Prepubertal male Sprague-Dawley rats (PND 35)
Comparator
Control
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
10 pg, 1 ng and 1 µg · intraperitoneal · 12 daysAs given in this study (rat).
Source sentences
Summary
Histomorphology and ultrastructure demonstrated, decrease in epithelial cell height, epithelial folding and dilatation of the organelles with kisspeptin treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this kisspeptin was administered as subchronic (12 days) twice daily i.p. dose at three different dosage regimens: 10 pg, 1 ng and 1 µg, to prepubertal male Sprague-Dawley rats (PND 35).
Report a problemFND-2312944903
04AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, percent DNA damage in prostate tissue was 20.74 after kisspeptin at 10 pg.
In plain wordsIn young male rats, kisspeptin at the lowest dose was linked to 20.74 percent DNA damage in prostate tissue.
Peptide
Kisspeptin-10
Outcome
Direction not reportedProstate DNA damage at 10 pg
Study
ratn: not reported in source
Prepubertal male Sprague-Dawley rats (PND 35)
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
10 pg · intraperitoneal · 12 daysAs given in this study (rat).
Measurements
DNA damage
20.74%
10 pg
Source sentences
Summary
Percent DNA damage to the prostatic tissue was 20.74 ± 2.18, 43.60 ± 2.39, and 58.18 ± 2.59 at 10 pg, 1 ng and 1 µg doses, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this kisspeptin was administered as subchronic (12 days) twice daily i.p. dose at three different dosage regimens: 10 pg, 1 ng and 1 µg, to prepubertal male Sprague-Dawley rats (PND 35).
Report a problemFND-2312944904
05AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, percent DNA damage in prostate tissue was 43.60 after kisspeptin at 1 ng.
In plain wordsIn young male rats, kisspeptin at the middle dose was linked to 43.60 percent DNA damage in prostate tissue.
Peptide
Kisspeptin-10
Outcome
Direction not reportedProstate DNA damage at 1 ng
Study
ratn: not reported in source
Prepubertal male Sprague-Dawley rats (PND 35)
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
1 ng · intraperitoneal · 12 daysAs given in this study (rat).
Measurements
DNA damage
43.6%
1 ng
Source sentences
Summary
Percent DNA damage to the prostatic tissue was 20.74 ± 2.18, 43.60 ± 2.39, and 58.18 ± 2.59 at 10 pg, 1 ng and 1 µg doses, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this kisspeptin was administered as subchronic (12 days) twice daily i.p. dose at three different dosage regimens: 10 pg, 1 ng and 1 µg, to prepubertal male Sprague-Dawley rats (PND 35).
Report a problemFND-2312944905
06AnimalAnimal study (in vivo)Safety outcome
In prepubertal male rats, percent DNA damage in prostate tissue was 58.18 after kisspeptin at 1 µg.
In plain wordsIn young male rats, kisspeptin at the highest dose was linked to 58.18 percent DNA damage in prostate tissue.
Peptide
Kisspeptin-10
Outcome
Direction not reportedProstate DNA damage at 1 µg
Study
ratn: not reported in source
Prepubertal male Sprague-Dawley rats (PND 35)
Outcome group
Organ injury · Reproductive and sexual health
Studied dose
1 µg · intraperitoneal · 12 daysAs given in this study (rat).
Measurements
DNA damage
58.18%
1 µg
Source sentences
Summary
Percent DNA damage to the prostatic tissue was 20.74 ± 2.18, 43.60 ± 2.39, and 58.18 ± 2.59 at 10 pg, 1 ng and 1 µg doses, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
To address this kisspeptin was administered as subchronic (12 days) twice daily i.p. dose at three different dosage regimens: 10 pg, 1 ng and 1 µg, to prepubertal male Sprague-Dawley rats (PND 35).
Report a problemFND-2312944906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.