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Study · In vitro (cells) · mouse · 2012

4 results

Carnosine protects brain microvascular endothelial cells against rotenone-induced oxidative stress injury through histamine H₁ and H₂ receptors in vitro.

Zhang L, Yao K, Fan Y, He P, Wang X, Hu W, Chen Z

Clinical and experimental pharmacology & physiology1 Dec 2012Cited by 17 (Europe PMC)

PMID23127196 (opens in a new tab)DOI10.1111/1440-1681.12019 (opens in a new tab)PepBankPUB-23127196
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In mouse endothelial cells exposed to rotenone, carnosine concentration-dependently decreased apoptotic cell numbers.

    In plain wordsIn cells from mouse brain vessels, carnosine reduced cell death after rotenone exposure.

    Peptide
    L-carnosine
    Outcome
    DecreaseApoptotic cells
    Study

    mousen: not reported in source

    Brain microvascular endothelial cells exposed to rotenone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 μmol/L-1 mmol/L · 30 min before 18 h rotenone exposureAs given in this study (mouse).

    Source sentences

    Summary
    Over the range 1 μmol/L-1 mmol/L, carnosine concentration-dependently decreased the number of apoptotic cells after 18 h exposure to rotenone.
    2 context sentences
    Summary · context
    Mouse brain microvascular endothelial cells were exposed to 1 μmol/L rotenone for 18 h.
    Summary · context
    In some experiments, carnosine (100 nmol/L-1 mmol/L) was added 30 min prior to rotenone exposure.
  2. 02LabIn vitro (cells)Efficacy outcome

    In mouse endothelial cells, carnosine restored mitochondrial membrane potential after 6 h of rotenone exposure.

    In plain wordsIn cells from mouse brain vessels, carnosine restored mitochondrial membrane potential after rotenone exposure.

    Peptide
    L-carnosine
    Outcome
    IncreaseMitochondrial membrane potential
    Study

    mousen: not reported in source

    Brain microvascular endothelial cells exposed to rotenone
    Outcome group
    Mitochondrial function · Nervous system and cognition
    Studied dose
    0.1 mmol/LAs given in this study (mouse).

    Source sentences

    Summary
    At 0.1 mmol/L, carnosine restored the decrease in mitochondrial membrane potential after 6 h exposure to 1 μmol/L rotenone and this effect was also reversed by the H1 and H2 receptor antagonists.
    2 context sentences
    Summary · context
    Mouse brain microvascular endothelial cells were exposed to 1 μmol/L rotenone for 18 h.
    Summary · context
    In some experiments, carnosine (100 nmol/L-1 mmol/L) was added 30 min prior to rotenone exposure.
  3. 03LabIn vitro (cells)Pharmacokinetics

    In mouse endothelial cells, intracellular carnosine increased as early as 1 h after carnosine treatment.

    In plain wordsIn cells from mouse brain vessels, carnosine levels increased as early as 1 h after treatment.

    Peptide
    L-carnosine
    Outcome
    IncreaseIntracellular carnosine
    Study

    mousen: not reported in source

    Brain microvascular endothelial cells exposed to rotenone
    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, intracellular carnosine levels increased as early as 1 h after carnosine treatment, whereas intracellular histamine levels increased 18 h after carnosine treatment.
    2 context sentences
    Summary · context
    Mouse brain microvascular endothelial cells were exposed to 1 μmol/L rotenone for 18 h.
    Summary · context
    In some experiments, carnosine (100 nmol/L-1 mmol/L) was added 30 min prior to rotenone exposure.
  4. 04LabIn vitro (cells)Mechanism

    In mouse endothelial cells, intracellular histamine increased 18 h after carnosine treatment.

    In plain wordsIn cells from mouse brain vessels, histamine levels increased 18 h after carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    IncreaseIntracellular histamine
    Study

    mousen: not reported in source

    Brain microvascular endothelial cells exposed to rotenone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, intracellular carnosine levels increased as early as 1 h after carnosine treatment, whereas intracellular histamine levels increased 18 h after carnosine treatment.
    2 context sentences
    Summary · context
    Mouse brain microvascular endothelial cells were exposed to 1 μmol/L rotenone for 18 h.
    Summary · context
    In some experiments, carnosine (100 nmol/L-1 mmol/L) was added 30 min prior to rotenone exposure.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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