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Study · In vitro (cells) · 2013

2 results

The melanocortin 4 receptor: oligomer formation, interaction sites and functional significance.

Chapman KL, Findlay JB

Biochimica et biophysica acta23 Oct 2012Cited by 10 (Europe PMC)

PMID23088915 (opens in a new tab)DOI10.1016/j.bbamem.2012.10.011 (opens in a new tab)PepBankPUB-23088915
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HEK-293 cells expressing MC4R, the receptor retained high affinity for NDP-MSH in the absence of the G-protein.

    In plain wordsIn lab cells, the MC4R receptor still bound NDP-MSH tightly when its G-protein partner was absent.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    No significant changeNDP-MSH affinity for MC4R without G-protein
    Study

    n: not reported in source

    HEK-293 cells expressing recombinant MC4R
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pharmacology of the agonist, NDP-MSH, indicates that the MC(4)R retains high affinity for the ligand in the absence of the G-protein but occupancy for the ligand is increased.
  2. 02LabIn vitro (cells)Activity measurement

    In HEK-293 cells expressing MC4R, occupancy of the receptor by NDP-MSH was increased in the absence of the G-protein.

    In plain wordsIn lab cells, more MC4R receptors were occupied by NDP-MSH when the G-protein partner was absent.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseNDP-MSH receptor occupancy without G-protein
    Study

    n: not reported in source

    HEK-293 cells expressing recombinant MC4R
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The pharmacology of the agonist, NDP-MSH, indicates that the MC(4)R retains high affinity for the ligand in the absence of the G-protein but occupancy for the ligand is increased.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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