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Study · Animal study (in vivo) · mouse · 2012

3 results

Teduglutide, a glucagon-like peptide 2 analogue: a novel protective agent with anti-apoptotic and anti-oxidant properties in mice with lung injury.

Arda-Pirincci P, Oztay F, Bayrak BB, Yanardag R, Bolkent S

Peptides8 Oct 2012Cited by 9 (Europe PMC)

PMID23059393 (opens in a new tab)DOI10.1016/j.peptides.2012.09.030 (opens in a new tab)PepBankPUB-23059393
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with TNF-α/Act D lung injury, teduglutide pretreatment reduced structural damage versus injury without pretreatment.

    In plain wordsIn mice with lung injury, teduglutide pretreatment reduced structural damage versus injury without pretreatment.

    Peptide
    Teduglutide
    Outcome
    DecreaseLung structural damage
    Study

    mousen: not reported in source

    TNF-α/Act D lung injury
    Comparator
    TNF-α/Act D without teduglutide pretreatment
    Outcome group
    Tissue Injury · Respiratory
    Studied dose
    200 μg/kg every 12h · subcutaneous · 10 consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Teduglutide pretreatment regressed the structural damage, cell apoptosis and oxidative stress by reducing lipid peroxidation in mice received TNF-α/Act D.
    1 context sentence
    Summary · context
    In the present study, possible cytoprotective and reparative effects of teduglutide were analyzed on a mouse model with lung injury induced by tumor necrosis factor-alpha (TNF-α) and actinomycin D (Act D).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with TNF-α/Act D lung injury, teduglutide pretreatment reduced cell apoptosis versus injury without pretreatment.

    In plain wordsIn mice with lung injury, teduglutide pretreatment reduced cell death versus injury without pretreatment.

    Peptide
    Teduglutide
    Outcome
    DecreasePulmonary cell apoptosis
    Study

    mousen: not reported in source

    TNF-α/Act D lung injury
    Comparator
    TNF-α/Act D without teduglutide pretreatment
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    200 μg/kg every 12h · subcutaneous · 10 consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Teduglutide pretreatment regressed the structural damage, cell apoptosis and oxidative stress by reducing lipid peroxidation in mice received TNF-α/Act D.
    1 context sentence
    Summary · context
    In the present study, possible cytoprotective and reparative effects of teduglutide were analyzed on a mouse model with lung injury induced by tumor necrosis factor-alpha (TNF-α) and actinomycin D (Act D).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with TNF-α/Act D lung injury, teduglutide pretreatment reduced lipid peroxidation versus injury without pretreatment.

    In plain wordsIn mice with lung injury, teduglutide pretreatment reduced lipid oxidation versus injury without pretreatment.

    Peptide
    Teduglutide
    Outcome
    DecreaseLipid peroxidation
    Study

    mousen: not reported in source

    TNF-α/Act D lung injury
    Comparator
    TNF-α/Act D without teduglutide pretreatment
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    200 μg/kg every 12h · subcutaneous · 10 consecutive daysAs given in this study (mouse).

    Source sentences

    Summary
    Teduglutide pretreatment regressed the structural damage, cell apoptosis and oxidative stress by reducing lipid peroxidation in mice received TNF-α/Act D.
    1 context sentence
    Summary · context
    In the present study, possible cytoprotective and reparative effects of teduglutide were analyzed on a mouse model with lung injury induced by tumor necrosis factor-alpha (TNF-α) and actinomycin D (Act D).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

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