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Study · Not a test of the peptide alone · 2013

7 results

Multiple functional involvement of thymosin beta-4 in tooth germ development.

Ookuma YF, Kiyoshima T, Kobayashi I, Nagata K, Wada H, Fujiwara H, Yamaza H, Nonaka K, Sakai H

Histochemistry and cell biology6 Oct 2012Cited by 10 (Europe PMC)

PMID23052839 (opens in a new tab)DOI10.1007/s00418-012-1033-1 (opens in a new tab)PepBankPUB-23052839
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneEx vivo tissueMechanism

    In cultured embryonic day 11.0 mouse mandibles, Tβ4 antisense knockdown inhibited tooth germ growth.

    In plain wordsIn cultured mouse embryo jaws, lowering Tβ4 slowed the growth of the tooth germ.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTooth germ growth after Tβ4 knockdown (E11.0)
    Study

    mousen: not reported in source

    cultured embryonic day 11.0 mouse mandibles
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    An inhibition assay using Tβ4 antisense sulfur-substituted oligodeoxynucleotide (AS S-ODN) in cultured embryonic day 11.0 (E11.0) mandibles showed a significant growth inhibition of the tooth germ.
    1 context sentence
    Summary · context
    In this study, we examined the functional implications of Tβ4 in the developmental course of the mouse lower first molar.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneEx vivo tissueMechanism

    In cultured embryonic day 15.0 mouse tooth germ, Tβ4 antisense knockdown caused no growth arrest.

    In plain wordsIn cultured older mouse embryo tooth germs, lowering Tβ4 did not stop growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeTooth germ growth after Tβ4 knockdown (E15.0)
    Study

    mousen: not reported in source

    cultured embryonic day 15.0 mouse tooth germ
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    However, no growth arrest of the cultured E15.0 tooth germ was observed by using Tβ4 AS S-ODN.
    1 context sentence
    Summary · context
    In this study, we examined the functional implications of Tβ4 in the developmental course of the mouse lower first molar.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneEx vivo tissueMechanism

    In cultured embryonic day 11.0 mouse mandibles, Tβ4 knockdown decreased expression of type II/III Runx2.

    In plain wordsIn cultured mouse embryo jaws, lowering Tβ4 reduced the level of the gene regulator Runx2.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseRunx2 expression after Tβ4 knockdown
    Study

    mousen: not reported in source

    cultured embryonic day 11.0 mouse mandibles
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The Tβ4 knockdown led to significantly decreased expression levels of type II/III runt-related transcription factor 2 (Runx2) and nucleolin (Ncl) in the cultured E11.0 mandibles.
    1 context sentence
    Summary · context
    In this study, we examined the functional implications of Tβ4 in the developmental course of the mouse lower first molar.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04LabNot a test of Thymosin beta-4 (human) aloneEx vivo tissueMechanism

    In cultured embryonic day 11.0 mouse mandibles, Tβ4 knockdown decreased expression of nucleolin (Ncl).

    In plain wordsIn cultured mouse embryo jaws, lowering Tβ4 reduced the level of the protein nucleolin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseNucleolin expression after Tβ4 knockdown
    Study

    mousen: not reported in source

    cultured embryonic day 11.0 mouse mandibles
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The Tβ4 knockdown led to significantly decreased expression levels of type II/III runt-related transcription factor 2 (Runx2) and nucleolin (Ncl) in the cultured E11.0 mandibles.
    1 context sentence
    Summary · context
    In this study, we examined the functional implications of Tβ4 in the developmental course of the mouse lower first molar.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In mDE6 dental epithelial cells, Tβ4 knockdown decreased secretion of matrix metalloproteinase-2.

    In plain wordsIn cells, lowering Tβ4 reduced the release of the enzyme Mmp-2.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMmp-2 secretion after Tβ4 knockdown
    Study

    mousen: not reported in source

    mDE6 dental epithelial cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    decreased secretion of matrix metalloproteinase (Mmp)-2
    1 context sentence
    Summary · context
    In this study, we examined the functional implications of Tβ4 in the developmental course of the mouse lower first molar.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  6. 06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In mDE6 dental epithelial cells, Tβ4 knockdown reduced cell motility.

    In plain wordsIn cells, lowering Tβ4 reduced how well the cells moved.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCell motility after Tβ4 knockdown
    Study

    mousen: not reported in source

    mDE6 dental epithelial cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    a reduced cell motility activity and upregulation of E-cadherin in dental epithelial mDE6 cells.
    1 context sentence
    Summary · context
    In this study, we examined the functional implications of Tβ4 in the developmental course of the mouse lower first molar.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  7. 07LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In mDE6 dental epithelial cells, Tβ4 knockdown upregulated E-cadherin.

    In plain wordsIn cells, lowering Tβ4 raised the level of E-cadherin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseE-cadherin expression after Tβ4 knockdown
    Study

    mousen: not reported in source

    mDE6 dental epithelial cells
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    upregulation of E-cadherin in dental epithelial mDE6 cells.
    1 context sentence
    Summary · context
    In this study, we examined the functional implications of Tβ4 in the developmental course of the mouse lower first molar.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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