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Study · Animal study (in vivo) · rat · 2012

5 results

The use of angiogenic-antimicrobial agents in experimental wounds in animals: problems and solutions.

Suman P, Ramachandran H, Sahakian S, Gill KZ, Horst BA, Modak SM, Hardy MA

Annals of the New York Academy of Sciences1 Oct 2012Cited by 2 (Europe PMC)

PMID23050814 (opens in a new tab)DOI10.1111/j.1749-6632.2012.06653.x (opens in a new tab)PepBankPUB-23050814
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with full-thickness wounds, thymosin beta‑4 alone gave 72% wound healing.

    In plain wordsIn rats with large skin wounds, thymosin beta‑4 alone gave 72% wound healing.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedWound healing with thymosin beta-4 alone
    Study

    ratn: not reported in source

    Full-thickness wounds, clean or infected
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Measurements

    Wound healing
    72%
    thymosin beta-4 alone

    Source sentences

    Summary
    Silvathymosin showed the fastest wound healing (85%) followed by silver sulfadiazine (84%) and Tβ4 (72%)
    1 context sentence
    Summary · context
    A topical combination (silvathymosin) of natural proangiogeneic protein thymosin β4 (Tβ4) and antimicrobial silver sulfadiazine was hypothesized to promote the healing of large, full-thickness, clean or infected wounds in rats.

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In rats with full-thickness wounds, silvathymosin (thymosin beta‑4 with silver sulfadiazine) showed the fastest wound healing, at 85%.

    In plain wordsIn rats with large skin wounds, a combination of thymosin beta‑4 and silver sulfadiazine gave the fastest healing, at 85%.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedWound healing with silvathymosin
    Study

    ratn: not reported in source

    Full-thickness wounds, clean or infected
    Outcome group
    Wound healing · Skin and wound

    Measurements

    Wound healing
    85%
    silvathymosin

    Source sentences

    Summary
    Silvathymosin showed the fastest wound healing (85%) followed by silver sulfadiazine (84%) and Tβ4 (72%).
    1 context sentence
    Summary · context
    A topical combination (silvathymosin) of natural proangiogeneic protein thymosin β4 (Tβ4) and antimicrobial silver sulfadiazine was hypothesized to promote the healing of large, full-thickness, clean or infected wounds in rats.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In rats with acute wounds, the combination of thymosin beta‑4 and silver sulfadiazine healed wounds more rapidly than either agent alone.

    In plain wordsIn rats with acute wounds, the combination of thymosin beta‑4 and silver sulfadiazine healed wounds faster than either agent alone.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAcute wound healing with silvathymosin versus each agent alone
    Study

    ratn: not reported in source

    Full-thickness wounds, clean or infected
    Comparator
    Thymosin beta-4 alone and silver sulfadiazine alone
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    These preliminary data demonstrate the more rapid acute wound healing properties of the combination formulation of thymosin β4 and silver sulfadiazine as compared to these agents alone.
    1 context sentence
    Summary · context
    A topical combination (silvathymosin) of natural proangiogeneic protein thymosin β4 (Tβ4) and antimicrobial silver sulfadiazine was hypothesized to promote the healing of large, full-thickness, clean or infected wounds in rats.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In rats with infected wounds, the thymosin beta‑4 and silvathymosin groups did not show similar wound healing.

    In plain wordsIn rats with infected wounds, healing in the thymosin beta‑4 group differed from healing in the silvathymosin group.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedHealing in infected wounds, thymosin beta-4 versus silvathymosin
    Study

    ratn: not reported in source

    Full-thickness wounds, clean or infected
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    In the infected groups, the healing pattern was different, as Tβ4 and silvathymosin groups did not show similar wound healing.
    1 context sentence
    Summary · context
    A topical combination (silvathymosin) of natural proangiogeneic protein thymosin β4 (Tβ4) and antimicrobial silver sulfadiazine was hypothesized to promote the healing of large, full-thickness, clean or infected wounds in rats.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In rats with acute wounds, VEGF and KI67 immunohistochemistry and histopathology agreed with the tempo of wound healing across the treatment groups.

    In plain wordsIn rats with acute wounds, tissue markers of new blood vessel growth matched how fast the wounds healed.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableVEGF and KI67 angiogenesis markers in acute wounds
    Study

    ratn: not reported in source

    Full-thickness wounds, clean or infected
    Outcome group
    Angiogenesis · Skin and wound

    Source sentences

    Summary
    Wound histopathology and VEGF and KI67 immunohistochemical assessment of angiogenesis was consistent and correlated well with the tempo of healing of the acute wounds.
    1 context sentence
    Summary · context
    A topical combination (silvathymosin) of natural proangiogeneic protein thymosin β4 (Tβ4) and antimicrobial silver sulfadiazine was hypothesized to promote the healing of large, full-thickness, clean or infected wounds in rats.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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