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Study · In vitro (cells) · 2012

3 results

Thymosin β4 stabilizes hypoxia-inducible factor-1α protein in an oxygen-independent manner.

Ock MS, Song KS, Kleinman H, Cha HJ

Annals of the New York Academy of Sciences1 Oct 2012Cited by 3 (Europe PMC)

PMID23045974 (opens in a new tab)DOI10.1111/j.1749-6632.2012.06657.x (opens in a new tab)PepBankPUB-23045974
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cell assays, thymosin beta‑4 peptide had no effect on VEGF promoter activity.

    In plain wordsIn lab tests, thymosin beta‑4 did not change VEGF promoter activity.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeVEGF promoter activity
    Study

    n: not reported in source

    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The Tβ4 peptide had no effect on either VEGF promoter activity or VEGF RNA stability.
    1 context sentence
    Summary · context
    To identify the mechanism of VEGF induction by Tβ4, we measured VEGF promoter activity and analyzed the effect of Tβ4 on VEGF RNA stability.
  2. 02LabIn vitro (cells)Mechanism

    In cell assays, thymosin beta‑4 peptide had no effect on VEGF RNA stability.

    In plain wordsIn lab tests, thymosin beta‑4 did not change how stable VEGF RNA was.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeVEGF RNA stability
    Study

    n: not reported in source

    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The Tβ4 peptide had no effect on either VEGF promoter activity or VEGF RNA stability.
    1 context sentence
    Summary · context
    To identify the mechanism of VEGF induction by Tβ4, we measured VEGF promoter activity and analyzed the effect of Tβ4 on VEGF RNA stability.
  3. 03LabIn vitro (cells)Mechanism

    In cells under normoxic conditions, thymosin beta‑4 increased the stability of HIF-1α protein.

    In plain wordsIn cells with normal oxygen, thymosin beta‑4 made the HIF-1α protein more stable.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHIF-1α protein stability under normoxia
    Study

    n: not reported in source

    Outcome group
    Angiogenesis · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We determined that Tβ4 increased the stability of HIF-1α protein under normoxic conditions.
    1 context sentence
    Summary · context
    To identify the mechanism of VEGF induction by Tβ4, we measured VEGF promoter activity and analyzed the effect of Tβ4 on VEGF RNA stability.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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