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Study · In vitro (cells) · 2012

2 results

Thymosin β4 affecting the cytoskeleton organization of the myofibroblasts.

Ehrlich HP, Hazard SW

Annals of the New York Academy of Sciences1 Oct 2012Cited by 8 (Europe PMC)

PMID23045973 (opens in a new tab)DOI10.1111/j.1749-6632.2012.06730.x (opens in a new tab)PepBankPUB-23045973
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human dermal fibroblasts plated at low density, thymosin beta‑4 prevented expression of alpha smooth muscle actin.

    In plain wordsIn cells, thymosin beta‑4 stopped human skin fibroblasts from making the myofibroblast marker alpha smooth muscle actin.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAlpha smooth muscle actin expression in fibroblasts
    Study

    humann: not reported in source

    Human dermal fibroblasts at low plating density
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treating low-density plated fibroblasts with Tβ4 prevents their expression of αSMA
    1 context sentence
    Summary · context
    When human dermal fibroblasts are plated at low density, upon reaching confluence, they all express α smooth muscle actin (αSMA) within their cytoplasmic stress fibers, morphologically defining them as myofibroblasts.
  2. 02LabIn vitro (cells)Mechanism

    In human dermal fibroblasts plated at low density, thymosin beta‑4 prevented the generation of an uneven distribution of microtubules in the cytoplasm.

    In plain wordsIn cells, thymosin beta‑4 stopped an uneven spread of microtubules inside human skin fibroblasts.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMicrotubule distribution in the cytoplasm
    Study

    humann: not reported in source

    Human dermal fibroblasts at low plating density
    Outcome group
    Cytoskeleton and cell structure · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treating low-density plated fibroblasts with Tβ4 prevents their expression of αSMA, as well as the generation an uneven distribution of microtubules within the cytoplasm.
    1 context sentence
    Summary · context
    When human dermal fibroblasts are plated at low density, upon reaching confluence, they all express α smooth muscle actin (αSMA) within their cytoplasmic stress fibers, morphologically defining them as myofibroblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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