Protective effects of thymosin β4 on carbon tetrachloride-induced acute hepatotoxicity in rats.

Reyes-Gordillo K, Shah R, Arellanes-Robledo J, Rojkind M, Lakshman MR

Annals of the New York Academy of Sciences1 Oct 2012Cited by 19 (Europe PMC)

PMID23045971DOI10.1111/j.1749-6632.2012.06728.xPepBankPUB-23045971

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with CCl4-induced acute liver injury, Tβ4 prevented necrosis.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented liver cell death.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHepatic necrosis
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with CCl4-induced acute liver injury, Tβ4 prevented inflammatory infiltration.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented inflammatory cells entering the liver.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseInflammatory infiltration
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Inflammation markers · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597102
03AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced acute liver injury, Tβ4 prevented upregulation of α1 and α2 collagen mRNA expression.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented a rise in scar-tissue collagen gene activity.
Peptide
Thymosin beta-4 (human)
Outcome
Decreaseα1 and α2 collagen mRNA expression
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597103
04AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced acute liver injury, Tβ4 prevented upregulation of α-SMA mRNA expression.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented a rise in activity of the α-SMA gene.
Peptide
Thymosin beta-4 (human)
Outcome
Decreaseα-SMA mRNA expression
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597104
05AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced acute liver injury, Tβ4 prevented upregulation of PDGF-β receptor mRNA expression.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented a rise in activity of the PDGF-β receptor gene.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePDGF-β receptor mRNA expression
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597105
06AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced acute liver injury, Tβ4 prevented upregulation of fibronectin mRNA expression.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented a rise in activity of the fibronectin gene.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseFibronectin mRNA expression
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597106
07AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced acute liver injury, Tβ4 prevented downregulation of PPARγ mRNA levels.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented a fall in activity of the PPARγ gene.
Peptide
Thymosin beta-4 (human)
Outcome
IncreasePPARγ mRNA expression
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597107
08AnimalAnimal study (in vivo)Mechanism
In rats with CCl4-induced acute liver injury, Tβ4 prevented upregulation of MECP2 mRNA levels.
In plain wordsIn rats with chemical liver injury, thymosin β4 prevented a rise in activity of the MECP2 gene.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseMECP2 mRNA expression
Study
ratn: not reported in source
carbon tetrachloride-induced acute hepatotoxicity
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Our studies thus far indicate that Tβ4 can prevent necrosis, inflammatory infiltration, and upregulation of α1(and 2) collagen, α-SMA, PDGF-β receptor, and fibronectin mRNA expression; in addition, Tβ4 can prevent downregulation of PPARγ and upregulation of MECP2 mRNA levels in acute liver injury.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we discuss our preliminary work on the protective effect of Tβ4 on carbon tetrachloride (CCl(4) )-induced acute hepatotoxicity.
Report a problemFND-2304597108

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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