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Study · In vitro (cells) · 2012

2 results

Thymosin β4 is rapidly internalized by cells and does not induce intracellular Ca2+ elevation.

Cierniewski CS, Sobierajska K, Selmi A, Kryczka J, Bednarek R

Annals of the New York Academy of Sciences1 Oct 2012Cited by 12 (Europe PMC)

PMID23045969 (opens in a new tab)DOI10.1111/j.1749-6632.2012.06685.x (opens in a new tab)PepBankPUB-23045969
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cells, stimulation with Tβ4 did not release Ca2+ from intracellular stores.

    In plain wordsIn cells, thymosin β4 did not trigger a release of calcium inside the cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCa2+ release from intracellular stores after Tβ4 stimulation
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data indicate that the release of Ca(2+) from intracellular stores following stimulation of cells with Tβ4 does not occur.
  2. 02LabIn vitro (cells)Mechanism

    In cells, Tβ4 became rapidly internalized.

    In plain wordsIn cells, thymosin β4 was quickly taken up into the cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCellular internalization of Tβ4
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Interestingly, Tβ4 becomes rapidly internalized, supporting the concept that it may express its activities via intracellular receptors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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