Differential modulation of gonadotropin responses to kisspeptin by aminoacidergic, peptidergic, and nitric oxide neurotransmission.

García-Galiano D, Pineda R, Roa J, Ruiz-Pino F, Sánchez-Garrido MA, Castellano JM, Aguilar E, Navarro VM, Pinilla L, Tena-Sempere M

American journal of physiology. Endocrinology and metabolism25 Sept 2012Cited by 28 (Europe PMC)

PMID23011064DOI10.1152/ajpendo.00250.2012PepBankPUB-23011064

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

01AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, blockade of NMDA and non-NMDA glutamate receptors variably decreased the LH response to Kp-10.
In plain wordsIn male rats, blocking glutamate receptors lowered the LH response to kisspeptin‑10 by varying amounts.
Peptide
Kisspeptin-10
Outcome
DecreaseLH response to Kp-10 after glutamate receptor blockade
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Blockade of ionotropic glutamate receptors (of the NMDA and non-NMDA type) variably decreased LH responses to Kp-10
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106401
02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, activation of ionotropic and metabotropic glutamate receptors did not further increase gonadotropin responses to Kp-10.
In plain wordsIn male rats, switching on glutamate receptors did not raise the hormone response to kisspeptin‑10 any further.
Peptide
Kisspeptin-10
Outcome
No significant changeGonadotropin response to Kp-10 after glutamate receptor activation
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
whereas activation of both ionotropic and metabotropic receptors, which enhanced LH and FSH release per se, failed to further increase gonadotropin responses to Kp-10.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106402
03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, coactivation of metabotropic glutamate receptors attenuated the LH response to Kp-10.
In plain wordsIn male rats, switching on a type of glutamate receptor lowered the LH response to kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
DecreaseLH response to Kp-10 after metabotropic glutamate receptor coactivation
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In fact, coactivation of metabotropic receptors attenuated LH and FSH responses to Kp-10.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106403
04AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, coactivation of metabotropic glutamate receptors attenuated the FSH response to Kp-10.
In plain wordsIn male rats, switching on a type of glutamate receptor lowered the FSH response to kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
DecreaseFSH response to Kp-10 after metabotropic glutamate receptor coactivation
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
In fact, coactivation of metabotropic receptors attenuated LH and FSH responses to Kp-10.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106404
05AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, selective activation of GABA(A) receptors decreased Kp-induced gonadotropin secretion.
In plain wordsIn male rats, switching on GABA(A) receptors lowered the hormone release caused by kisspeptin.
Peptide
Kisspeptin-10
Outcome
DecreaseKp-induced gonadotropin secretion after GABA(A) receptor activation
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Selective activation of GABA(A) receptors decreased Kp-induced gonadotropin secretion
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106405
06AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, GABA(A) receptor blockade elicited robust LH and FSH bursts and protracted responses to Kp-10 when combined with GABA(B) receptor inhibition.
In plain wordsIn male rats, blocking both GABA receptor types gave strong, longer LH and FSH responses to kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
IncreaseLH and FSH responses to Kp-10 after GABA(A) and GABA(B) blockade
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
whereas their blockade elicited robust LH and FSH bursts and protracted responses to Kp-10 when combined with GABA(B) receptor inhibition.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106406
07AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, blockade of dynorphin signaling at kappa-opioid receptors enhanced the LH response to Kp-10.
In plain wordsIn male rats, blocking dynorphin signaling made the LH response to kisspeptin‑10 larger.
Peptide
Kisspeptin-10
Outcome
IncreaseLH response to Kp-10 after dynorphin signaling blockade
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Blockade of Dyn signaling (at κ-opioid receptors) enhanced LH responses to Kp-10
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106407
08AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, activation of dynorphin and neurokinin B signaling modestly reduced Kp-induced LH release.
In plain wordsIn male rats, switching on dynorphin and neurokinin B signaling slightly lowered the LH release caused by kisspeptin.
Peptide
Kisspeptin-10
Outcome
DecreaseKp-induced LH release after dynorphin and NKB activation
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
whereas activation of Dyn and NKB signaling modestly reduced Kp-induced LH and FSH release.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106408
09AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, activation of dynorphin and neurokinin B signaling modestly reduced Kp-induced FSH release.
In plain wordsIn male rats, switching on dynorphin and neurokinin B signaling slightly lowered the FSH release caused by kisspeptin.
Peptide
Kisspeptin-10
Outcome
DecreaseKp-induced FSH release after dynorphin and NKB activation
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
whereas activation of Dyn and NKB signaling modestly reduced Kp-induced LH and FSH release.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106409
10AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, melanin-concentrating hormone (MCH) decreased basal LH secretion.
In plain wordsIn male rats, MCH lowered the baseline release of LH.
Peptide
Kisspeptin-10
Outcome
DecreaseBasal LH secretion after MCH
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Finally, MCH decreased basal LH secretion and modestly reduced FSH responses to Kp-10, whereas LH responses to Kp-10 were protracted after inhibition of NO synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106410
11AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, MCH modestly reduced the FSH response to Kp-10.
In plain wordsIn male rats, MCH slightly lowered the FSH response to kisspeptin‑10.
Peptide
Kisspeptin-10
Outcome
DecreaseFSH response to Kp-10 after MCH
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
and modestly reduced FSH responses to Kp-10
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106411
12AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism
In male rats, LH responses to Kp-10 were protracted after inhibition of nitric oxide synthesis.
In plain wordsIn male rats, blocking nitric oxide production made the LH response to kisspeptin‑10 last longer.
Peptide
Kisspeptin-10
Outcome
IncreaseLH response to Kp-10 after inhibition of nitric oxide synthesis
Study
ratn: not reported in source
Male rats with pharmacological manipulation of neurotransmission
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
whereas LH responses to Kp-10 were protracted after inhibition of NO synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
We characterize herein the impact of manipulations of key aminoacidergic (glutamate and GABA), peptidergic (NKB, Dyn, and MCH), and gaseous [nitric oxide (NO)] neurotransmission on gonadotropin responses to Kp-10 in male rats.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2301106412

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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