Effects of repeated injection of kisspeptin-10 on the initiation of egg-laying in juvenile quail.

Ni Y, Huang Y, Xiao Y, Wu J, Qian F, Grossmann R, Zhao R

Animal reproduction science16 Aug 2012Cited by 8 (Europe PMC)

PMID22944168DOI10.1016/j.anireprosci.2012.08.022PepBankPUB-22944168

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In juvenile female quail, repeated Kp-10 injections increased the ratio of egg laying versus saline control at both doses.
In plain wordsIn young female quail, daily kisspeptin‑10 injections raised the share of birds that laid eggs compared with saline.
Peptide
Kisspeptin-10
Outcome
IncreaseRatio of egg laying
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 nmol and 100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
The ratio of egg laying of quail in the L and H groups was notably increased compared to that of the Con group (P<0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416801
02AnimalAnimal study (in vivo)Efficacy outcome
In juvenile female quail, the increase in egg laying with Kp-10 paralleled earlier ovarian growth.
In plain wordsIn young female quail, kisspeptin‑10 was linked with earlier growth of the ovary.
Peptide
Kisspeptin-10
Outcome
IncreaseOvarian growth
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 nmol and 100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
which paralleled earlier ovarian growth and increases in circulating estrogen (E(2)) concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416802
03AnimalAnimal study (in vivo)Efficacy outcome
In juvenile female quail, the increase in egg laying with Kp-10 paralleled increases in circulating estrogen concentrations.
In plain wordsIn young female quail, kisspeptin‑10 was linked with higher blood estrogen levels.
Peptide
Kisspeptin-10
Outcome
IncreaseCirculating estrogen (E2)
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 nmol and 100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
which paralleled earlier ovarian growth and increases in circulating estrogen (E(2)) concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416803
04AnimalAnimal study (in vivo)Mechanism
In juvenile female quail, high-dose Kp-10 up-regulated hypothalamic GnRH-I mRNA expression.
In plain wordsIn young female quail, high-dose kisspeptin‑10 raised the activity of the GnRH-I gene in the brain.
Peptide
Kisspeptin-10
Outcome
IncreaseHypothalamic GnRH-I mRNA expression
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
In the hypothalamus, gonadotropin-releasing hormone-I (GnRH-I) mRNA expression was markedly up-regulated
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416804
05AnimalAnimal study (in vivo)Mechanism
In juvenile female quail, high-dose Kp-10 down-regulated hypothalamic gonadotropin-inhibiting hormone mRNA.
In plain wordsIn young female quail, high-dose kisspeptin‑10 lowered the activity of the gonadotropin-inhibiting hormone gene in the brain.
Peptide
Kisspeptin-10
Outcome
DecreaseHypothalamic gonadotropin-inhibiting hormone mRNA
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
whereas the level of gonadotropin-inhibiting hormone mRNA was down-regulated by high-dose Kp-10 (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416805
06AnimalAnimal study (in vivo)Mechanism
In juvenile female quail, high-dose Kp-10 up-regulated pituitary GnRH receptor type II mRNA expression.
In plain wordsIn young female quail, high-dose kisspeptin‑10 raised the activity of the GnRH receptor type II gene in the pituitary gland.
Peptide
Kisspeptin-10
Outcome
IncreasePituitary GnRH receptor type II mRNA
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
In the pituitary gland, expression of GnRH receptor type II, but not type I mRNA was significantly up-regulated by high-dose Kp-10 administration (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416806
07AnimalAnimal study (in vivo)Mechanism
In juvenile female quail, high-dose Kp-10 did not significantly change pituitary GnRH receptor type I mRNA expression.
In plain wordsIn young female quail, high-dose kisspeptin‑10 did not change the GnRH receptor type I gene activity in the pituitary gland.
Peptide
Kisspeptin-10
Outcome
No significant changePituitary GnRH receptor type I mRNA
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
In the pituitary gland, expression of GnRH receptor type II, but not type I mRNA was significantly up-regulated by high-dose Kp-10 administration (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416807
08AnimalAnimal study (in vivo)Mechanism
In juvenile female quail, low-dose and high-dose Kp-10 decreased pituitary FSH gene expression versus control.
In plain wordsIn young female quail, kisspeptin‑10 lowered FSH gene activity in the pituitary gland compared with saline.
Peptide
Kisspeptin-10
Outcome
DecreasePituitary FSH mRNA expression
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 nmol and 100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
Moreover, compared with the Con group, follicle-stimulating hormone (FSH) gene expression in the pituitary was significantly decreased in the L and H groups (P<0.05), whereas luteinizing hormone (LH) mRNA expression was significantly increased in the H, but not the L group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416808
09AnimalAnimal study (in vivo)Mechanism
In juvenile female quail, high-dose Kp-10 increased pituitary LH mRNA expression versus control.
In plain wordsIn young female quail, high-dose kisspeptin‑10 raised LH gene activity in the pituitary gland compared with saline.
Peptide
Kisspeptin-10
Outcome
IncreasePituitary LH mRNA expression, high dose
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
Moreover, compared with the Con group, follicle-stimulating hormone (FSH) gene expression in the pituitary was significantly decreased in the L and H groups (P<0.05), whereas luteinizing hormone (LH) mRNA expression was significantly increased in the H, but not the L group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416809
10AnimalAnimal study (in vivo)Mechanism
In juvenile female quail, low-dose Kp-10 did not significantly increase pituitary LH mRNA expression.
In plain wordsIn young female quail, low-dose kisspeptin‑10 did not raise LH gene activity in the pituitary gland.
Peptide
Kisspeptin-10
Outcome
No significant changePituitary LH mRNA expression, low dose
Study
quailn: not reported in source
Juvenile female quail
Comparator
Saline control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 nmol · intraperitoneal · 3 weeksAs given in this study (quail).
Source sentences
Summary
Moreover, compared with the Con group, follicle-stimulating hormone (FSH) gene expression in the pituitary was significantly decreased in the L and H groups (P<0.05), whereas luteinizing hormone (LH) mRNA expression was significantly increased in the H, but not the L group (P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effects of Kp on the initiation of egg laying in birds, juvenile female quail were given daily intraperitoneal injections of 300μl saline (control, Con), or 10nmol (low dosage, L) or 100nmol (high dosage, H) kisspeptin-10 (Kp-10) dissolved in 300μl saline for 3 weeks.
Report a problemFND-2294416810

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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