Effect of beta-alanine and carnosine supplementation on muscle contractility in mice.

Everaert I, Stegen S, Vanheel B, Taes Y, Derave W

Medicine and science in sports and exercise1 Jan 2013Cited by 53 (Europe PMC)

PMID22895378DOI10.1249/mss.0b013e31826cdb68PepBankPUB-22895378

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Activity measurement
In mice, 1.8% carnosine supplementation markedly increased muscle carnosine versus controls.
In plain wordsIn mice, carnosine supplementation increased muscle carnosine compared with controls.
Peptide
L-carnosine
Outcome
IncreaseMuscle carnosine
Study
micen: not reported in source
male Naval Medical Research Institute mice
Comparator
control mice
Outcome group
Pharmacokinetics · Musculoskeletal
Studied dose
1.8% · drinking water · 8-12 wkAs given in this study (mice).
Source sentences
Summary
Only supplementation with 1.8% carnosine and 1.2% beta-alanine resulted in markedly higher carnosine (up to +160%) and anserine levels (up to +46%) compared with control mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Male Naval Medical Research Institute mice (n = 66) were control fed or supplemented with either carnosine (0.1%, 0.5%, or 1.8%) or beta-alanine (0.6 or 1.2%) in their drinking water for 8-12 wk.
Summary · context
Soleus and extensor digitorum longus (EDL) were tested for in vitro contractile properties, and carnosine, anserine, and taurine content were measured in EDL and tibialis anterior by high-performance liquid chromatography.
Report a problemFND-2289537801
02AnimalAnimal study (in vivo)Activity measurement
In mice, 1.8% carnosine supplementation markedly increased muscle anserine versus controls.
In plain wordsIn mice, carnosine supplementation increased muscle anserine compared with controls.
Peptide
L-carnosine
Outcome
IncreaseMuscle anserine
Study
micen: not reported in source
male Naval Medical Research Institute mice
Comparator
control mice
Outcome group
Pharmacokinetics · Musculoskeletal
Studied dose
1.8% · drinking water · 8-12 wkAs given in this study (mice).
Source sentences
Summary
Only supplementation with 1.8% carnosine and 1.2% beta-alanine resulted in markedly higher carnosine (up to +160%) and anserine levels (up to +46%) compared with control mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Male Naval Medical Research Institute mice (n = 66) were control fed or supplemented with either carnosine (0.1%, 0.5%, or 1.8%) or beta-alanine (0.6 or 1.2%) in their drinking water for 8-12 wk.
Summary · context
Soleus and extensor digitorum longus (EDL) were tested for in vitro contractile properties, and carnosine, anserine, and taurine content were measured in EDL and tibialis anterior by high-performance liquid chromatography.
Report a problemFND-2289537802
03AnimalAnimal study (in vivo)Activity measurement
In mice, 0.1% and 0.5% carnosine did not produce markedly higher muscle carnosine levels versus controls.
In plain wordsIn mice, lower carnosine doses did not markedly increase muscle carnosine compared with controls.
Peptide
L-carnosine
Outcome
Direction not reportedMuscle carnosine at lower carnosine doses
Study
micen: not reported in source
male Naval Medical Research Institute mice
Comparator
control mice
Outcome group
Pharmacokinetics · Musculoskeletal
Studied dose
0.1% or 0.5% · drinking water · 8-12 wkAs given in this study (mice).
Source sentences
Summary
Only supplementation with 1.8% carnosine and 1.2% beta-alanine resulted in markedly higher carnosine (up to +160%) and anserine levels (up to +46%) compared with control mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Male Naval Medical Research Institute mice (n = 66) were control fed or supplemented with either carnosine (0.1%, 0.5%, or 1.8%) or beta-alanine (0.6 or 1.2%) in their drinking water for 8-12 wk.
Report a problemFND-2289537803
04AnimalAnimal study (in vivo)Activity measurement
In mice, 0.1% and 0.5% carnosine did not produce markedly higher muscle anserine levels versus controls.
In plain wordsIn mice, lower carnosine doses did not markedly increase muscle anserine compared with controls.
Peptide
L-carnosine
Outcome
Direction not reportedMuscle anserine at lower carnosine doses
Study
micen: not reported in source
male Naval Medical Research Institute mice
Comparator
control mice
Outcome group
Pharmacokinetics · Musculoskeletal
Studied dose
0.1% or 0.5% · drinking water · 8-12 wkAs given in this study (mice).
Source sentences
Summary
Only supplementation with 1.8% carnosine and 1.2% beta-alanine resulted in markedly higher carnosine (up to +160%) and anserine levels (up to +46%) compared with control mice.
1 context sentence(design, population, supporting numbers)
Summary · context
Male Naval Medical Research Institute mice (n = 66) were control fed or supplemented with either carnosine (0.1%, 0.5%, or 1.8%) or beta-alanine (0.6 or 1.2%) in their drinking water for 8-12 wk.
Report a problemFND-2289537804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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