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Study · Measured the body's own peptide · 2012

6 results

Thymosin β4 is a novel potential prognostic marker in gastrointestinal stromal tumors.

Can B, Karagoz F, Yildiz L, Yildirim A, Kefeli M, Gonullu G, Kandemir B

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica24 Mar 2012Cited by 8 (Europe PMC)

PMID22882257 (opens in a new tab)DOI10.1111/j.1600-0463.2012.02887.x (opens in a new tab)PepBankPUB-22882257
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In 60 gastrointestinal stromal tumors, increased Tβ4 expression was found in 26 (43.3%).

    In plain wordsIn 60 stomach and bowel tumours, the body's own thymosin β4 was raised in 26 of them.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableProportion of GISTs with increased Tβ4 expression
    Study

    n = 60

    Outcome group
    Tumor growth · Cancer

    Measurements

    Tumors with increased Tβ4 expression
    26 tumors
    60 GISTs
    Tumors with increased Tβ4 expression
    43.3%
    60 GISTs

    Source sentences

    Summary
    Increased expression of Tβ(4) and VEGF was observed in 26 (43.3%) and in 19 (31.6%) of the tumors, respectively.
    1 context sentence
    Summary · context
    Retrospectively, 60 GISTs were re-examined and immunohistochemistry for Tβ(4) and VEGF was performed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In gastrointestinal stromal tumors, Tβ4 expression was positively correlated with VEGF expression (p < 0.01).

    In plain wordsIn stomach and bowel tumours, higher natural thymosin β4 went with higher VEGF.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCorrelation of Tβ4 with VEGF expression
    Study

    n = 60

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ(4) expression was positively correlated with VEGF expression (p < 0.01).
    1 context sentence
    Summary · context
    Retrospectively, 60 GISTs were re-examined and immunohistochemistry for Tβ(4) and VEGF was performed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In gastrointestinal stromal tumors, Tβ4 expression was significantly associated with tumor size (p = 0.00).

    In plain wordsIn stomach and bowel tumours, natural thymosin β4 was linked to tumour size.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAssociation of Tβ4 expression with tumor size
    Study

    n = 60

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ(4) and VEGF expression were significantly associated with tumor size (p = 0.00 and p = 0.02, respectively) and high mitosis (p = 0.03 and p = 0.00, respectively).
    1 context sentence
    Summary · context
    Retrospectively, 60 GISTs were re-examined and immunohistochemistry for Tβ(4) and VEGF was performed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In gastrointestinal stromal tumors, Tβ4 expression was significantly associated with high mitosis (p = 0.03).

    In plain wordsIn stomach and bowel tumours, natural thymosin β4 was linked to a high rate of cell division.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAssociation of Tβ4 expression with high mitosis
    Study

    n = 60

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ(4) and VEGF expression were significantly associated with tumor size (p = 0.00 and p = 0.02, respectively) and high mitosis (p = 0.03 and p = 0.00, respectively).
    1 context sentence
    Summary · context
    Retrospectively, 60 GISTs were re-examined and immunohistochemistry for Tβ(4) and VEGF was performed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In gastrointestinal stromal tumors, Tβ4 expression was positively associated with pleomorphism (p = 0.01).

    In plain wordsIn stomach and bowel tumours, higher natural thymosin β4 was linked to more varied cell shapes.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseAssociation of Tβ4 expression with pleomorphism
    Study

    n = 60

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Although Tβ(4) expression was positively associated with pleomorphism (p = 0.01), VEGF expression was positively associated with necrosis (p = 0.03).
    1 context sentence
    Summary · context
    Retrospectively, 60 GISTs were re-examined and immunohistochemistry for Tβ(4) and VEGF was performed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In gastrointestinal stromal tumors, Tβ4 expression was related to local recurrence and/or metastasis (p = 0.03).

    In plain wordsIn stomach and bowel tumours, natural thymosin β4 was linked to the tumour coming back or spreading.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAssociation of Tβ4 expression with local recurrence and/or metastasis
    Study

    n = 60

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Tβ(4) expression was related with local recurrence and/or metastasis (p = 0.03)
    1 context sentence
    Summary · context
    Retrospectively, 60 GISTs were re-examined and immunohistochemistry for Tβ(4) and VEGF was performed.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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