High diagnostic accuracy of subcutaneous Triptorelin test compared with GnRH test for diagnosing central precocious puberty in girls.

Freire AV, Escobar ME, Gryngarten MG, Arcari AJ, Ballerini MG, Bergadá I, Ropelato MG

Clinical endocrinology1 Mar 2013Cited by 36 (Europe PMC)

PMID22845185DOI10.1111/j.1365-2265.2012.04517.xPepBankPUB-22845185

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialActivity measurement
In girls with premature breast development, adding estradiol to the triptorelin LH test increased diagnostic efficiency to 96%.
In plain wordsIn girls with premature breast development, adding estradiol to the triptorelin LH test increased diagnostic efficiency to 96%.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseCombined LH or estradiol diagnostic efficiency
Study
n = 46
Comparator
LH-only test
Outcome group
Diagnostic test performance · Endocrine and hormones
Measurements
Sensitivity
0.94 proportion
LH-3 h or maximal estradiol at 24 h, specificity 1.00
Specificity
1 proportion
LH-3 h or maximal estradiol at 24 h
Diagnostic efficiency
96%
LH-3 h or maximal estradiol at 24 h
Source sentences
Summary
Considering either LH-3 h or maximal estradiol response at 24 h (cut-off value, 295 pm), maintaining the specificity at 1.00, the test sensitivity increased to 0.94 (95% CI: 0.80-0.99) and the diagnostic efficiency to 96%.
2 context sentences(design, population, supporting numbers)
Summary · context
A prospective, case-control, randomized clinical trial was performed.
Summary · context
Forty-six girls with premature breast development randomly underwent two tests: (i) intravenous GnRH 100 μg, (ii) subcutaneous Triptorelin acetate (0.1 mg/m(2), to a maximum of 0.1 mg) with blood sampling at 0, 3 and 24 h for LH, FSH and estradiol ascertainment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2284518505
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls with premature breast development, the triptorelin LH test had sensitivity 0.76 for central precocious puberty.
In plain wordsIn girls with premature breast development, the triptorelin LH test had sensitivity 0.76 for central precocious puberty.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableLH-based diagnostic sensitivity
Study
n = 33
Outcome group
Diagnostic test performance · Endocrine and hormones
Measurements
Sensitivity
0.76 proportion
LH-based test
Source sentences
Summary
Using receiver operating characteristic curves, maximal LH response (LH-3 h) under Triptorelin test ≥ 7 IU/l by immunofluorometric assay (IFMA) or ≥ 8 IU/l by electrochemiluminescence immunoassay (ECLIA) confirmed the diagnosis of CPP with specificity of 1.00 (95% CI: 0.75-1.00) and sensitivity 0.76…
3 context sentences(design, population, supporting numbers)
Summary · context
Clinical features were similar between CPP (n = 33) and PT (n = 13) groups.
Summary · context
A prospective, case-control, randomized clinical trial was performed.
Summary · context
Forty-six girls with premature breast development randomly underwent two tests: (i) intravenous GnRH 100 μg, (ii) subcutaneous Triptorelin acetate (0.1 mg/m(2), to a maximum of 0.1 mg) with blood sampling at 0, 3 and 24 h for LH, FSH and estradiol ascertainment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2284518502
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls with premature breast development, adding estradiol to the triptorelin LH test increased sensitivity to 0.94.
In plain wordsIn girls with premature breast development, adding estradiol to the triptorelin LH test increased sensitivity to 0.94.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseCombined LH or estradiol diagnostic sensitivity
Study
n = 33
Comparator
LH-only test
Outcome group
Diagnostic test performance · Endocrine and hormones
Measurements
Sensitivity
0.94 proportion
combined LH or estradiol response
Source sentences
Summary
Considering either LH-3 h or maximal estradiol response at 24 h (cut-off value, 295 pm), maintaining the specificity at 1.00, the test sensitivity increased to 0.94 (95% CI: 0.80-0.99) and the diagnostic efficiency to 96%.
3 context sentences(design, population, supporting numbers)
Summary · context
Clinical features were similar between CPP (n = 33) and PT (n = 13) groups.
Summary · context
A prospective, case-control, randomized clinical trial was performed.
Summary · context
Forty-six girls with premature breast development randomly underwent two tests: (i) intravenous GnRH 100 μg, (ii) subcutaneous Triptorelin acetate (0.1 mg/m(2), to a maximum of 0.1 mg) with blood sampling at 0, 3 and 24 h for LH, FSH and estradiol ascertainment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2284518504
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls with premature breast development, the triptorelin LH test had specificity 1.00 for central precocious puberty.
In plain wordsIn girls with premature breast development, the triptorelin LH test had specificity 1.00 for central precocious puberty.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableLH-based diagnostic specificity
Study
n = 13
Outcome group
Diagnostic test performance · Endocrine and hormones
Measurements
Specificity
1 proportion
LH-based test
Source sentences
Summary
Using receiver operating characteristic curves, maximal LH response (LH-3 h) under Triptorelin test ≥ 7 IU/l by immunofluorometric assay (IFMA) or ≥ 8 IU/l by electrochemiluminescence immunoassay (ECLIA) confirmed the diagnosis of CPP with specificity of 1.00 (95% CI: 0.75-1.00) and sensitivity 0.76…
3 context sentences(design, population, supporting numbers)
Summary · context
Clinical features were similar between CPP (n = 33) and PT (n = 13) groups.
Summary · context
A prospective, case-control, randomized clinical trial was performed.
Summary · context
Forty-six girls with premature breast development randomly underwent two tests: (i) intravenous GnRH 100 μg, (ii) subcutaneous Triptorelin acetate (0.1 mg/m(2), to a maximum of 0.1 mg) with blood sampling at 0, 3 and 24 h for LH, FSH and estradiol ascertainment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2284518501
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneObservational studyActivity measurement
In girls with premature breast development, the combined LH or estradiol triptorelin test maintained specificity 1.00.
In plain wordsIn girls with premature breast development, the combined LH or estradiol triptorelin test maintained specificity 1.00.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableCombined LH or estradiol diagnostic specificity
Study
n = 13
Outcome group
Diagnostic test performance · Endocrine and hormones
Measurements
Specificity
1 proportion
combined LH or estradiol response
Source sentences
Summary
Considering either LH-3 h or maximal estradiol response at 24 h (cut-off value, 295 pm), maintaining the specificity at 1.00, the test sensitivity increased to 0.94 (95% CI: 0.80-0.99) and the diagnostic efficiency to 96%.
3 context sentences(design, population, supporting numbers)
Summary · context
Clinical features were similar between CPP (n = 33) and PT (n = 13) groups.
Summary · context
A prospective, case-control, randomized clinical trial was performed.
Summary · context
Forty-six girls with premature breast development randomly underwent two tests: (i) intravenous GnRH 100 μg, (ii) subcutaneous Triptorelin acetate (0.1 mg/m(2), to a maximum of 0.1 mg) with blood sampling at 0, 3 and 24 h for LH, FSH and estradiol ascertainment.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2284518503

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Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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