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Study · Animal study (in vivo) · mouse · 2012

11 results

Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice.

Zhang X, Urbieta-Caceres VH, Eirin A, Bell CC, Crane JA, Tang H, Jordan KL, Oh YK, Zhu XY, Korsmo MJ, Bachar AR, Cohen P, Lerman A, Lerman LO

Life sciences20 Jul 2012Cited by 54 (Europe PMC)

PMID22820173 (opens in a new tab)PMCIDPMC3703734 (opens in a new tab)DOI10.1016/j.lfs.2012.07.010 (opens in a new tab)PepBankPUB-22820173
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ApoE deficient mice on a high-cholesterol diet, humanin restored the diet-induced increase in renal cortical microvascular spatial density.

    In plain wordsIn mice on a high-cholesterol diet, humanin brought kidney small-vessel density back toward normal.

    Peptide
    Humanin
    Outcome
    DecreaseCortical microvascular spatial density
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Cortical microvascular spatial density and media/lumen area ratio were significantly increased in high-cholesterol diet fed ApoE deficient mice, but restored by HN.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In ApoE deficient mice on a high-cholesterol diet, humanin restored the diet-induced increase in the media/lumen area ratio.

    In plain wordsIn mice on a high-cholesterol diet, humanin brought a kidney blood-vessel wall measure back toward normal.

    Peptide
    Humanin
    Outcome
    DecreaseMedia/lumen area ratio of renal vessels
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Cortical microvascular spatial density and media/lumen area ratio were significantly increased in high-cholesterol diet fed ApoE deficient mice, but restored by HN.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In ApoE deficient mice on a high-cholesterol diet, humanin up-regulated renal expression of the anti-angiogenic protein angiostatin.

    In plain wordsIn mice on a high-cholesterol diet, humanin raised kidney levels of a protein that limits new blood-vessel growth.

    Peptide
    Humanin
    Outcome
    IncreaseRenal angiostatin expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    HN up-regulated the renal expressions of anti-angiogenic proteins angiostatin and TSP-1, and inhibited angiopoietin-1.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In ApoE deficient mice on a high-cholesterol diet, humanin up-regulated renal expression of the anti-angiogenic protein TSP-1.

    In plain wordsIn mice on a high-cholesterol diet, humanin raised kidney levels of a protein that limits new blood-vessel growth.

    Peptide
    Humanin
    Outcome
    IncreaseRenal TSP-1 expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    HN up-regulated the renal expressions of anti-angiogenic proteins angiostatin and TSP-1, and inhibited angiopoietin-1.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In ApoE deficient mice on a high-cholesterol diet, humanin inhibited renal angiopoietin-1.

    In plain wordsIn mice on a high-cholesterol diet, humanin lowered kidney levels of a blood-vessel growth protein.

    Peptide
    Humanin
    Outcome
    DecreaseRenal angiopoietin-1 expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    HN up-regulated the renal expressions of anti-angiogenic proteins angiostatin and TSP-1, and inhibited angiopoietin-1.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In ApoE deficient mice on a high-cholesterol diet, humanin down-regulated renal MCP-1.

    In plain wordsIn mice on a high-cholesterol diet, humanin lowered a kidney inflammation marker.

    Peptide
    Humanin
    Outcome
    DecreaseRenal MCP-1 expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    HN attenuated inflammation by down-regulating MCP-1, TNF-alpha and osteopontin.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In ApoE deficient mice on a high-cholesterol diet, humanin down-regulated renal TNF-alpha.

    In plain wordsIn mice on a high-cholesterol diet, humanin lowered a kidney inflammation marker.

    Peptide
    Humanin
    Outcome
    DecreaseRenal TNF-alpha expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    HN attenuated inflammation by down-regulating MCP-1, TNF-alpha and osteopontin.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In ApoE deficient mice on a high-cholesterol diet, humanin down-regulated renal osteopontin.

    In plain wordsIn mice on a high-cholesterol diet, humanin lowered a kidney inflammation marker.

    Peptide
    Humanin
    Outcome
    DecreaseRenal osteopontin expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Inflammation markers · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    HN attenuated inflammation by down-regulating MCP-1, TNF-alpha and osteopontin.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In ApoE deficient mice on a high-cholesterol diet, humanin only tended to restore renal pSTAT3.

    In plain wordsIn mice on a high-cholesterol diet, humanin showed only a trend toward restoring a kidney signaling protein.

    Peptide
    Humanin
    Outcome
    No significant changeRenal pSTAT3 expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    HN also tended to restore pSTAT3 and attenuated Bax expression, suggesting blunted apoptosis.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In ApoE deficient mice on a high-cholesterol diet, humanin attenuated renal Bax expression, suggesting blunted apoptosis.

    In plain wordsIn mice on a high-cholesterol diet, humanin lowered a kidney cell-death marker.

    Peptide
    Humanin
    Outcome
    DecreaseRenal Bax expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    attenuated Bax expression, suggesting blunted apoptosis.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In ApoE deficient mice on a high-cholesterol diet, humanin treatment alleviated kidney collagen IV expression.

    In plain wordsIn mice on a high-cholesterol diet, humanin lowered a kidney scarring marker.

    Peptide
    Humanin
    Outcome
    DecreaseRenal collagen IV expression
    Study

    mousen = 24

    ApoE deficient mice on a 16-week high-cholesterol diet
    Comparator
    Saline
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 mg/kg/day · intraperitoneal · 16 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Kidney collagen IV expression was alleviated by HN treatment.
    1 context sentence
    Summary · context
    Twenty-four ApoE deficient mice were fed a 16-week high-cholesterol diet supplemented with saline or HN (4mg/kg/day, intraperitoneal).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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