Controlled release of thymosin β4 from injected collagen-chitosan hydrogels promotes angiogenesis and prevents tissue loss after myocardial infarction.

Chiu LL, Reis LA, Momen A, Radisic M

Regenerative medicine1 Jul 2012Cited by 23 (Europe PMC)

PMID22817626DOI10.2217/rme.12.35PepBankPUB-22817626

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In rats with myocardial infarction, a Tβ4-encapsulated hydrogel reduced tissue loss (13%) compared with no treatment (58%).
In plain wordsIn rats with a heart attack, a gel that releases Tβ4 reduced tissue loss to 13%, versus 58% with no treatment.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTissue loss after myocardial infarction versus MI only
Study
ratn: not reported in source
left anterior descending artery ligation (myocardial infarction)
Comparator
No treatment (MI only)
Outcome group
Heart function · Cardiovascular
Measurements
Tissue loss
13%
Tβ4 hydrogel
Tissue loss
58%
MI only
Source sentences
Summary
Tβ4-encapsulated hydrogel (thymosin) significantly reduced tissue loss post-MI (13 ± 4%), compared with 58 ± 3% and 30 ± 8% tissue loss for no treatment (MI only) and Tβ4-free hydrogel (control).
1 context sentence(design, population, supporting numbers)
Summary · context
We injected collagen-chitosan hydrogel with controlled release of Tβ4 into the infarct after performing left anterior descending artery ligation in rats.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2281762601
02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In rats with myocardial infarction, a Tβ4-encapsulated hydrogel reduced tissue loss (13%) compared with Tβ4-free hydrogel (30%).
In plain wordsIn rats with a heart attack, a gel that releases Tβ4 reduced tissue loss to 13%, versus 30% with the same gel without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTissue loss after myocardial infarction versus Tβ4-free hydrogel
Study
ratn: not reported in source
left anterior descending artery ligation (myocardial infarction)
Comparator
Tβ4-free hydrogel
Outcome group
Heart function · Cardiovascular
Measurements
Tissue loss
13%
Tβ4 hydrogel
Tissue loss
30%
Tβ4-free hydrogel
Source sentences
Summary
Tβ4-encapsulated hydrogel (thymosin) significantly reduced tissue loss post-MI (13 ± 4%), compared with 58 ± 3% and 30 ± 8% tissue loss for no treatment (MI only) and Tβ4-free hydrogel (control).
1 context sentence(design, population, supporting numbers)
Summary · context
We injected collagen-chitosan hydrogel with controlled release of Tβ4 into the infarct after performing left anterior descending artery ligation in rats.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2281762602
03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In rats with myocardial infarction, the Tβ4 hydrogel group had significantly more Factor VIII-positive blood vessels with diameter >50 µm than the MI-only group (p < 0.0001).
In plain wordsIn rats with a heart attack, a gel that releases Tβ4 gave clearly more large blood vessels (over 50 µm) than no treatment.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseFactor VIII-positive blood vessels (>50 µm) versus MI only
Study
ratn: not reported in source
left anterior descending artery ligation (myocardial infarction)
Comparator
No treatment (MI only)
Outcome group
Angiogenesis · Cardiovascular
Source sentences
Summary
Significantly more Factor VIII-positive blood vessels with diameter >50 µm were in the thymosin group compared with both MI only and control (p < 0.0001), showing Tβ4-induced vascularization.
1 context sentence(design, population, supporting numbers)
Summary · context
We injected collagen-chitosan hydrogel with controlled release of Tβ4 into the infarct after performing left anterior descending artery ligation in rats.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2281762603
04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In rats with myocardial infarction, the Tβ4 hydrogel group had significantly more Factor VIII-positive blood vessels with diameter >50 µm than the Tβ4-free hydrogel group (p < 0.0001).
In plain wordsIn rats with a heart attack, a gel that releases Tβ4 gave more large blood vessels (over 50 µm) than the same gel without it.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseFactor VIII-positive blood vessels (>50 µm) versus Tβ4-free hydrogel
Study
ratn: not reported in source
left anterior descending artery ligation (myocardial infarction)
Comparator
Tβ4-free hydrogel
Outcome group
Angiogenesis · Cardiovascular
Source sentences
Summary
Significantly more Factor VIII-positive blood vessels with diameter >50 µm were in the thymosin group compared with both MI only and control (p < 0.0001), showing Tβ4-induced vascularization.
1 context sentence(design, population, supporting numbers)
Summary · context
We injected collagen-chitosan hydrogel with controlled release of Tβ4 into the infarct after performing left anterior descending artery ligation in rats.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2281762604
05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism
In rats with myocardial infarction, wall thickness correlated positively with mature blood vessel density (r = 0.9319).
In plain wordsIn rats with a heart attack, thicker heart walls went with more mature blood vessels.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCorrelation of wall thickness with mature blood vessel density
Study
ratn: not reported in source
left anterior descending artery ligation (myocardial infarction)
Outcome group
Heart function · Cardiovascular
Measurements
Correlation r
0.9319
wall thickness vs mature vessel density
Source sentences
Summary
Wall thickness was positively correlated with the mature blood vessel density (r = 0.9319; p < 0.0001).
1 context sentence(design, population, supporting numbers)
Summary · context
We injected collagen-chitosan hydrogel with controlled release of Tβ4 into the infarct after performing left anterior descending artery ligation in rats.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2281762605

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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