Effect of pramlintide on prandial glycemic excursions during closed-loop control in adolescents and young adults with type 1 diabetes.

Weinzimer SA, Sherr JL, Cengiz E, Kim G, Ruiz JL, Carria L, Voskanyan G, Roy A, Tamborlane WV

Diabetes care18 Jul 2012Cited by 99 (Europe PMC)

PMID22815298PMCIDPMC3447854DOI10.2337/dc12-0330PepBankPUB-22815298

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanNon-randomized trialEfficacy outcome
In adolescents and young adults with T1DM, pramlintide delayed peak blood glucose compared with closed-loop insulin alone.
In plain wordsIn adolescents and young adults with T1DM, pramlintide delayed peak blood glucose compared with closed-loop insulin alone.
Peptide
Pramlintide (Symlin)
Outcome
IncreaseTime to peak blood glucose
Study
n = 8
Comparator
Closed-loop insulin delivery alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
30 μg before meals · injection · 24 hAs given in this study (human).
Measurements
Time to peak glucose
2.5 h
pramlintide
Time to peak glucose
1.5 h
closed-loop alone
Source sentences
Summary
CLP was associated with overall delayed time to peak BG (2.5 ± 0.9 vs. 1.5 ± 0.5 h; P < 0.0001) and reduced magnitude of glycemic excursion (88 ± 42 vs. 113 ± 32 mg/dL; P = 0.006) compared with CL alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight subjects (4 female; age, 15-28 years; A1C, 7.5 ± 0.7%) were studied for 48 h on a CL insulin-delivery system with a proportional integral derivative algorithm with insulin feedback: 24 h on CL control alone (CL) and 24 h on CL control plus 30-μg premeal injections of pramlintide (CLP).
Report a problemFND-2281529801
02HumanNon-randomized trialEfficacy outcome
In adolescents and young adults with T1DM, pramlintide reduced glucose excursions compared with closed-loop insulin alone.
In plain wordsIn adolescents and young adults with T1DM, pramlintide reduced glucose excursions compared with closed-loop insulin alone.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseGlycemic excursion magnitude
Study
n = 8
Comparator
Closed-loop insulin delivery alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
30 μg before meals · injection · 24 hAs given in this study (human).
Measurements
Glycemic excursion
88 mg/dL
pramlintide
Glycemic excursion
113 mg/dL
closed-loop alone
Source sentences
Summary
CLP was associated with overall delayed time to peak BG (2.5 ± 0.9 vs. 1.5 ± 0.5 h; P < 0.0001) and reduced magnitude of glycemic excursion (88 ± 42 vs. 113 ± 32 mg/dL; P = 0.006) compared with CL alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight subjects (4 female; age, 15-28 years; A1C, 7.5 ± 0.7%) were studied for 48 h on a CL insulin-delivery system with a proportional integral derivative algorithm with insulin feedback: 24 h on CL control alone (CL) and 24 h on CL control plus 30-μg premeal injections of pramlintide (CLP).
Report a problemFND-2281529802
03HumanNon-randomized trialEfficacy outcome
In adolescents and young adults with T1DM, pramlintide reduced glucose excursions particularly at lunch and dinner, with higher premeal insulin concentrations.
In plain wordsIn adolescents and young adults with T1DM, pramlintide reduced glucose excursions particularly at lunch and dinner, with higher premeal insulin concentrations.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseLunch and dinner glycemic excursions
Study
n = 8
Comparator
Closed-loop insulin delivery alone
Outcome group
Glycemic control · Metabolic and weight
Studied dose
30 μg before meals · injection · 24 hAs given in this study (human).
Source sentences
Summary
Pramlintide effects on glycemic excursions were particularly evident at lunch and dinner, in association with higher premeal insulin concentrations at those mealtimes.
1 context sentence(design, population, supporting numbers)
Summary · context
Eight subjects (4 female; age, 15-28 years; A1C, 7.5 ± 0.7%) were studied for 48 h on a CL insulin-delivery system with a proportional integral derivative algorithm with insulin feedback: 24 h on CL control alone (CL) and 24 h on CL control plus 30-μg premeal injections of pramlintide (CLP).
Report a problemFND-2281529803

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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