Promoting effects of thymosin β4 on granulation tissue and new bone formation after tooth extraction in rats.

Matsuo K, Akasaki Y, Adachi K, Zhang M, Ishikawa A, Jimi E, Nishihara T, Hosokawa R

Oral surgery, oral medicine, oral pathology and oral radiology26 Aug 2011Cited by 15 (Europe PMC)

PMID22732845DOI10.1016/j.tripleo.2011.05.025PepBankPUB-22732845

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after tooth extraction, a TB4 partial peptide suppressed apoptosis in the extraction socket versus saline.
In plain wordsIn rats, a piece of thymosin β4 reduced cell death in the tooth socket compared with saline.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseApoptosis in extraction socket
Study
ratn: not reported in source
mandibular first molar extraction socket
Comparator
Phosphate-buffered saline
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · intraperitoneal · 6 daysAs given in this study (rat).
Source sentences
Summary
The overall data showed that TB4 treatment suppressed apoptosis and inflammation; it accelerated the process of wound healing, including new bone formation.
2 context sentences(design, population, supporting numbers)
Summary · context
After extraction of the rats' mandibular first molar teeth, a synthetic partial peptide of TB4 was injected intraperitoneally at the time of extraction and every day thereafter for 6 days.
Summary · context
Control subjects for the treatment received identical amounts of phosphate-buffered saline solution in the same manner.
Report a problemFND-2273284501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after tooth extraction, a TB4 partial peptide suppressed inflammation in the extraction socket versus saline.
In plain wordsIn rats, a piece of thymosin β4 reduced inflammation in the tooth socket compared with saline.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseInflammation in extraction socket
Study
ratn: not reported in source
mandibular first molar extraction socket
Comparator
Phosphate-buffered saline
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated · intraperitoneal · 6 daysAs given in this study (rat).
Source sentences
Summary
The overall data showed that TB4 treatment suppressed apoptosis and inflammation; it accelerated the process of wound healing, including new bone formation.
2 context sentences(design, population, supporting numbers)
Summary · context
After extraction of the rats' mandibular first molar teeth, a synthetic partial peptide of TB4 was injected intraperitoneally at the time of extraction and every day thereafter for 6 days.
Summary · context
Control subjects for the treatment received identical amounts of phosphate-buffered saline solution in the same manner.
Report a problemFND-2273284502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats after tooth extraction, a TB4 partial peptide accelerated wound healing versus saline.
In plain wordsIn rats, a piece of thymosin β4 sped up healing of the tooth socket compared with saline.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseWound healing after tooth extraction
Study
ratn: not reported in source
mandibular first molar extraction socket
Comparator
Phosphate-buffered saline
Outcome group
Wound healing · Skin and wound
Studied dose
Dose not stated · intraperitoneal · 6 daysAs given in this study (rat).
Source sentences
Summary
The overall data showed that TB4 treatment suppressed apoptosis and inflammation; it accelerated the process of wound healing, including new bone formation.
2 context sentences(design, population, supporting numbers)
Summary · context
After extraction of the rats' mandibular first molar teeth, a synthetic partial peptide of TB4 was injected intraperitoneally at the time of extraction and every day thereafter for 6 days.
Summary · context
Control subjects for the treatment received identical amounts of phosphate-buffered saline solution in the same manner.
Report a problemFND-2273284503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats after tooth extraction, a TB4 partial peptide accelerated new bone formation versus saline.
In plain wordsIn rats, a piece of thymosin β4 sped up new bone growth in the tooth socket compared with saline.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseNew bone formation after tooth extraction
Study
ratn: not reported in source
mandibular first molar extraction socket
Comparator
Phosphate-buffered saline
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · intraperitoneal · 6 daysAs given in this study (rat).
Source sentences
Summary
The overall data showed that TB4 treatment suppressed apoptosis and inflammation; it accelerated the process of wound healing, including new bone formation.
2 context sentences(design, population, supporting numbers)
Summary · context
After extraction of the rats' mandibular first molar teeth, a synthetic partial peptide of TB4 was injected intraperitoneally at the time of extraction and every day thereafter for 6 days.
Summary · context
Control subjects for the treatment received identical amounts of phosphate-buffered saline solution in the same manner.
Report a problemFND-2273284504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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