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Study · Not a test of the peptide alone · 2012

2 results

Pharmacokinetic/pharmacodynamic model of the testosterone effects of triptorelin administered in sustained release formulations in patients with prostate cancer.

Romero E, Vélez de Mendizabal N, Cendrós JM, Peraire C, Bascompta E, Obach R, Trocóniz IF

The Journal of pharmacology and experimental therapeutics12 Jun 2012Cited by 26 (Europe PMC)

PMID22691297 (opens in a new tab)DOI10.1124/jpet.112.195560 (opens in a new tab)PepBankPUB-22691297
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  1. 01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialPharmacokinetics

    In a population PK/PD model, the typical triptorelin receptor equilibrium dissociation constant was 0.931 ng/ml.

    In plain wordsComputer modelling estimated a triptorelin receptor dissociation constant of 0.931 ng/ml.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableReceptor equilibrium dissociation constant
    Study

    n: not reported in source

    Population PK/PD model
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    K(D)
    0.931 ng/ml
    typical population value

    Source sentences

    Summary
    The typical population values of K(D), the receptor equilibrium dissociation constant of triptorelin, and C(TRP_min) to keep 95% of the patients castrated were 0.931 and 0.0609 ng/ml, respectively.
    2 context sentences
    Summary · context
    A total of eight healthy male volunteers and 74 patients with prostate cancer received one or two doses of triptorelin injected subcutaneously or intramuscularly.
    Summary · context
    Pharmacokinetic (serum concentration of triptorelin) and pharmacodynamic (TST levels in serum) data were analyzed by using the population approach with NONMEM software (http://www.iconplc.com/technology/products/nonmem/).

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

  2. 02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialPharmacokinetics

    The model estimated a triptorelin concentration of 0.0609 ng/ml to maintain castration in 95% of patients.

    In plain wordsComputer modelling estimated a minimum triptorelin concentration of 0.0609 ng/ml for the specified testosterone suppression target.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicableMinimum concentration for castration
    Study

    n: not reported in source

    Population PK/PD model
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    C(TRP_min)
    0.0609 ng/ml
    95% of patients castrated

    Source sentences

    Summary
    The typical population values of K(D), the receptor equilibrium dissociation constant of triptorelin, and C(TRP_min) to keep 95% of the patients castrated were 0.931 and 0.0609 ng/ml, respectively.
    2 context sentences
    Summary · context
    A total of eight healthy male volunteers and 74 patients with prostate cancer received one or two doses of triptorelin injected subcutaneously or intramuscularly.
    Summary · context
    Pharmacokinetic (serum concentration of triptorelin) and pharmacodynamic (TST levels in serum) data were analyzed by using the population approach with NONMEM software (http://www.iconplc.com/technology/products/nonmem/).

    In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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