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Study · In vitro (cells) · 2012

3 results

Thymosin β4 promotes the migration of endothelial cells without intracellular Ca2+ elevation.

Selmi A, Malinowski M, Brutkowski W, Bednarek R, Cierniewski CS

Experimental cell research29 May 2012Cited by 11 (Europe PMC)

PMID22652458 (opens in a new tab)DOI10.1016/j.yexcr.2012.04.009 (opens in a new tab)PepBankPUB-22652458
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HUVECs, external treatment with Tβ4 and its two mutants enhanced cell migration.

    In plain wordsIn cells, thymosin β4 and its two altered forms made blood vessel lining cells move more.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEndothelial cell migration
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    External treatment of HUVECs with Tβ4 and its mutants deprived of the N-terminal tetrapeptide AcSDKP (Tβ4(AcSDKPT/4A)) or the actin-binding sequence KLKKTET (Tβ4(KLKKTET/7A)) resulted in enhanced cell migration and formation of tubular structures in Matrigel.
  2. 02LabIn vitro (cells)Activity measurement

    In HUVECs, external treatment with Tβ4 and its two mutants enhanced the formation of tubular structures in Matrigel.

    In plain wordsIn cells, thymosin β4 and its two altered forms increased the formation of tube-like structures.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTubular structure formation in Matrigel
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    External treatment of HUVECs with Tβ4 and its mutants deprived of the N-terminal tetrapeptide AcSDKP (Tβ4(AcSDKPT/4A)) or the actin-binding sequence KLKKTET (Tβ4(KLKKTET/7A)) resulted in enhanced cell migration and formation of tubular structures in Matrigel.
  3. 03LabIn vitro (cells)Mechanism

    In HUVECs, the increased cell motility caused by Tβ4 was not associated with intracellular Ca2+ elevation.

    In plain wordsIn cells, thymosin β4 made cells move more but did not raise calcium inside the cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeIntracellular Ca2+ elevation
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Surprisingly, the increased cell motility caused by Tβ4 was not associated with the intracellular Ca(2+) elevation monitored with Fluo-4 NW or Fura-2 AM.
    1 context sentence
    Summary · context
    External treatment of HUVECs with Tβ4 and its mutants deprived of the N-terminal tetrapeptide AcSDKP (Tβ4(AcSDKPT/4A)) or the actin-binding sequence KLKKTET (Tβ4(KLKKTET/7A)) resulted in enhanced cell migration and formation of tubular structures in Matrigel.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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