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Study · Measured the body's own peptide · 2012

3 results

Tonic control of kisspeptin release in prepubertal monkeys: implications to the mechanism of puberty onset.

Kurian JR, Keen KL, Guerriero KA, Terasawa E

Endocrinology14 May 2012Cited by 41 (Europe PMC)

PMID22585828 (opens in a new tab)PMCIDPMC3380308 (opens in a new tab)DOI10.1210/en.2012-1221 (opens in a new tab)PepBankPUB-22585828
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In prepubertal monkeys, infusion of the GABA(A) antagonist bicuculline (1 µM) increased the release of the animal's own kisspeptin in the medial basal hypothalamus.

    In plain wordsIn young monkeys, a drug that blocks GABA raised the body's own kisspeptin release in a brain region.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKisspeptin release in prepubertal monkeys
    Study

    monkeyn: not reported in source

    Microdialysis of the medial basal hypothalamus in prepubertal and midpubertal monkeys
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    We found that bicuculline at 1 μM dramatically stimulates kisspeptin release in the medial basal hypothalamus of prepubertal monkeys
    1 context sentence
    Summary · context
    To test this hypothesis we examined the effects of bicuculline infusion on kisspeptin release using a microdialysis method.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In midpubertal monkeys, bicuculline had little effect on the release of the animal's own kisspeptin in the medial basal hypothalamus.

    In plain wordsIn older, midpuberty monkeys, the GABA-blocking drug had little effect on the body's own kisspeptin release.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKisspeptin release in midpubertal monkeys
    Study

    monkeyn: not reported in source

    Microdialysis of the medial basal hypothalamus in prepubertal and midpubertal monkeys
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    but had little effect on kisspeptin release in midpubertal monkeys.
    1 context sentence
    Summary · context
    To test this hypothesis we examined the effects of bicuculline infusion on kisspeptin release using a microdialysis method.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 03AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Mechanism

    In monkeys, the kisspeptin antagonist peptide 234 blocked the bicuculline-induced stimulation of GnRH release.

    In plain wordsIn monkeys, a drug that blocks kisspeptin signaling stopped the GnRH release that bicuculline had caused.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseBicuculline-induced GnRH release with kisspeptin antagonist peptide 234
    Study

    monkeyn: not reported in source

    Microdialysis of the medial basal hypothalamus in prepubertal and midpubertal monkeys
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    We found that inhibition of kisspeptin signaling blocked the bicuculline-induced stimulation of GnRH release
    1 context sentence
    Summary · context
    We further examined whether bicuculline-induced GnRH release is blocked by the presence of the kisspeptin antagonist, peptide 234.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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