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Study · Non-randomized trial · n = 17 · 2012

4 results

Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle.

Chan YM, Butler JP, Sidhoum VF, Pinnell NE, Seminara SB

The Journal of clinical endocrinology and metabolism10 May 2012Cited by 62 (Europe PMC)

PMID22577171 (opens in a new tab)PMCIDPMC3410261 (opens in a new tab)DOI10.1210/jc.2012-1282 (opens in a new tab)PepBankPUB-22577171
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy women in the midluteal and preovulatory phases, an intravenous kisspeptin bolus was followed by LH pulses in all women.

    In plain wordsIn healthy women in the luteal and preovulatory phases, a kisspeptin dose was followed by an LH pulse in every woman.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH pulse after bolus in luteal and preovulatory women
    Study

    n = 17

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.24 nmol/kg · intravenous · single bolusAs given in this study (human).

    Source sentences

    Summary
    LH pulses were observed immediately after kisspeptin administration in all luteal and preovulatory women.
    1 context sentence
    Summary · context
    Ten women in the early follicular phase, three women in the late follicular (preovulatory) phase, and 14 women in the midluteal phase received a bolus of kisspeptin 112-121 0.24 nmol/kg iv.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy women in the early follicular phase, only half had unambiguous LH responses to the kisspeptin bolus.

    In plain wordsIn healthy women in the early follicular phase, only half had a clear LH response to the kisspeptin dose.

    Peptide
    Kisspeptin-10
    Outcome
    MixedUnambiguous kisspeptin response in early follicular women
    Study

    n = 10

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.24 nmol/kg · intravenous · single bolusAs given in this study (human).

    Source sentences

    Summary
    However, only half the women in the early follicular phase had unambiguous kisspeptin responses.
    1 context sentence
    Summary · context
    Ten women in the early follicular phase, three women in the late follicular (preovulatory) phase, and 14 women in the midluteal phase received a bolus of kisspeptin 112-121 0.24 nmol/kg iv.
  3. 03HumanNon-randomized trialEfficacy outcome

    In women in the early to midfollicular phase, raising the kisspeptin dose from 0.24 to 0.72 nmol/kg did not increase the LH response.

    In plain wordsIn women in the early to midfollicular phase, a threefold higher kisspeptin dose did not raise the LH response.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLH response at higher kisspeptin dose in early to midfollicular women
    Study

    n: not reported in source

    Comparator
    Kisspeptin 0.24 nmol/kg
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.24 and 0.72 nmol/kg · intravenous · single bolusAs given in this study (human).

    Source sentences

    Summary
    Increasing the kisspeptin dose did not increase the LH response in early to midfollicular phase women.
    1 context sentence
    Summary · context
    An additional four women in the early to midfollicular phase received kisspeptin 112-121 0.72 nmol/kg iv.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy women, kisspeptin did not appear to reset the GnRH pulse generator.

    In plain wordsIn healthy women, kisspeptin did not appear to reset the brain's GnRH pulse generator, unlike in men.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeReset of the GnRH pulse generator
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    0.24 nmol/kg · intravenous · single bolusAs given in this study (human).

    Source sentences

    Summary
    Kisspeptin did not appear to reset the GnRH pulse generator in women as it does in men.
    1 context sentence
    Summary · context
    Ten women in the early follicular phase, three women in the late follicular (preovulatory) phase, and 14 women in the midluteal phase received a bolus of kisspeptin 112-121 0.24 nmol/kg iv.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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