Changes of the thiol levels in the corneas of the diabetic rats: effect of carnosine, aspirin and a combination eye drops.

Shi Q, Yan H

International journal of ophthalmology18 Sept 2010Cited by 3 (Europe PMC)

PMID22553556PMCIDPMC3340641DOI10.3980/j.issn.2222-3959.2010.03.07PepBankPUB-22553556

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, carnosine eye drops increased corneal thiol levels versus the untreated group (P<0.05).
In plain wordsIn rats with diabetes, carnosine eye drops increased corneal thiol levels compared with no treatment.
Peptide
L-carnosine
Outcome
IncreaseCorneal thiol levels
Study
ratn: not reported in source
streptozotocin-induced diabetes
Comparator
untreated diabetic group
Outcome group
Oxidative stress · Eye
Studied dose
one drop of 10g/L Car eye drops · ocular instillation · 8 weeksAs given in this study (rat).
Source sentences
Summary
In the corneas, the levels of thiols were declined in the untreated, Asp-treated group and combination-treated group, but they went up in Car-treated group. The levels of thiols in the Car-treated groups were much higher than that in the untreated group, and there was statistically significant diffe…
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetes was induced by injection of streptozotocin (STZ) in the Sprague-Dawley (SD) rats.
Summary · context
One treated group rats were treated by instillation of one drop of 10g/L Car eye drops, another were treated by 0.5g/L Asp eye drops and the last group were treated alternately by Car 10g/L and Asp 0.5g/L eye drops for a period of 8 weeks.
Report a problemFND-2255355601

Studies that did not test the peptide alone1

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

02AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Efficacy outcome
In diabetic rats, corneal thiol levels declined in the carnosine and aspirin combination group.
In plain wordsIn rats with diabetes, corneal thiol levels declined with the carnosine and aspirin combination.
Peptide
L-carnosine
Outcome
DecreaseCorneal thiol levels with combination
Study
ratn: not reported in source
streptozotocin-induced diabetes
Outcome group
Oxidative stress · Eye
Source sentences
Summary
In the corneas, the levels of thiols were declined in the untreated, Asp-treated group and combination-treated group, but they went up in Car-treated group.
2 context sentences(design, population, supporting numbers)
Summary · context
Diabetes was induced by injection of streptozotocin (STZ) in the Sprague-Dawley (SD) rats.
Summary · context
One treated group rats were treated by instillation of one drop of 10g/L Car eye drops, another were treated by 0.5g/L Asp eye drops and the last group were treated alternately by Car 10g/L and Asp 0.5g/L eye drops for a period of 8 weeks.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-2255355602

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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