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Study · Measured the body's own peptide · 2012

4 results

Kisspeptin-54 levels are increased in patients with colorectal cancer.

Canbay E, Ergen A, Bugra D, Yamaner S, Eraltan IY, Buyukuncu Y, Bulut T

World journal of surgery1 Sept 2012Cited by 13 (Europe PMC)

PMID22552499 (opens in a new tab)DOI10.1007/s00268-012-1636-7 (opens in a new tab)PepBankPUB-22552499
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with colorectal cancer, plasma kisspeptin‑54 levels were significantly higher than in healthy controls.

    In plain wordsIn people with colorectal cancer, the body's own kisspeptin‑54 levels in blood were higher than in healthy people.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreasePlasma kisspeptin-54 in CRC patients versus controls
    Study

    n = 140

    Comparator
    Age-matched healthy controls
    Outcome group
    Tumor growth · Cancer

    Measurements

    Plasma kisspeptin-54
    86.2
    CRC patients
    Plasma kisspeptin-54
    49
    controls

    Source sentences

    Summary
    Plasma Kisspeptin-54 levels were significantly higher in CRC patients (86.2 ± 20.5) than in controls (49 ± 12.7; p < 0.005).
    1 context sentence
    Summary · context
    Plasma Kisspeptin-54 levels were quantified using enzyme-immunoassay (EIA) kits from blood samples of 81 patients with CRC at their initial staging and 59 age-matched healthy controls.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Plasma kisspeptin‑54 at a cutoff of 46 ng/ml had an area under the curve of 0.766 for detecting colorectal cancer.

    In plain wordsIn people with colorectal cancer, the body's own kisspeptin‑54 level in blood showed moderate accuracy for telling patients from healthy people.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    Not applicableDiagnostic accuracy of plasma kisspeptin-54 for CRC
    Study

    n = 140

    Outcome group
    Tumor growth · Cancer

    Measurements

    AUC
    0.766
    CRC detection
    Cutoff
    46 ng/ml
    kisspeptin-54
    Sensitivity
    63%
    cutoff 46 ng/ml
    Specificity
    81.4%
    cutoff 46 ng/ml

    Source sentences

    Summary
    The cutoff value for Kisspeptin-54 detection was determined as 46 ng/ml, and area under curve (AUC) value was 0.766 with sensitivity 63 %, specificity 81.4 %, positive predictive value 82.2 %, negative predictive value 61.5 %, positive likelihood ratio 3.38, and negative likelihood ratio 0.46.
    1 context sentence
    Summary · context
    Plasma Kisspeptin-54 levels were quantified using enzyme-immunoassay (EIA) kits from blood samples of 81 patients with CRC at their initial staging and 59 age-matched healthy controls.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with colorectal cancer, increased plasma kisspeptin‑54 correlated with nodal involvement.

    In plain wordsIn people with colorectal cancer, higher natural kisspeptin‑54 levels were linked to lymph node involvement.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreaseCorrelation of plasma kisspeptin-54 with nodal involvement
    Study

    n = 81

    Outcome group
    Tumor growth · Cancer

    Measurements

    Spearman rs
    0.345
    nodal involvement

    Source sentences

    Summary
    Increased plasma Kisspeptin-54 levels were significantly correlated with nodal involvement of CRC (Spearman, rs = 0.345, p = 0.002).
    1 context sentence
    Summary · context
    Plasma Kisspeptin-54 levels were quantified using enzyme-immunoassay (EIA) kits from blood samples of 81 patients with CRC at their initial staging and 59 age-matched healthy controls.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In patients with colorectal cancer, plasma kisspeptin‑54 was an independent predictive marker for lymph node metastases.

    In plain wordsIn people with colorectal cancer, the body's own kisspeptin‑54 level in blood was linked to lymph node spread.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    IncreasePlasma kisspeptin-54 as predictor of lymph node metastases
    Study

    n = 81

    Outcome group
    Tumor growth · Cancer

    Measurements

    Exp(B)
    2.053
    lymph node metastases

    Source sentences

    Summary
    Kisspeptin-54 was also found to be an independent predictive marker for lymph node metastases of CRC (p = 0; Exp(B): 2.053; 95 % CI, 1.255-2.851).
    1 context sentence
    Summary · context
    Plasma Kisspeptin-54 levels were quantified using enzyme-immunoassay (EIA) kits from blood samples of 81 patients with CRC at their initial staging and 59 age-matched healthy controls.

    This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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