NAD(+) administration significantly attenuates synchrotron radiation X-ray-induced DNA damage and structural alterations of rodent testes.

Sheng C, Chen H, Wang B, Liu T, Hong Y, Shao J, He X, Ma Y, Nie H, Liu N, Xia W, Ying W

International journal of physiology, pathophysiology and pharmacology1 Mar 2012Cited by 20 (Europe PMC)

PMID22518270PMCIDPMC3328394PepBankPUB-22518270

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rat testes, 125 mg/kg NAD significantly decreased double-strand DNA damage induced by 40 Gy SR X-ray.
In plain wordsIn rats, 125 mg/kg NAD reduced testicular DNA damage induced by 40 Gy SR X-ray.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseDouble-strand DNA damage at 125 mg/kg
Study
ratn: not reported in source
Synchrotron radiation X-ray-exposed testes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
125 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
We found that 40 Gy of SR X-ray induced a massive increase in double-strand DNA damage, as assessed by both immunostaining and Western blot of phosphorylated H2AX levels, which was significantly decreased by intraperitoneally (i.p.) administered NAD(+) at doses of 125 and 625 mg/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we used the testes of rats as a model to characterize SR X-ray-induced tissue damage, and to test our hypothesis that NAD(+) administration can prevent SR X-ray-induced injury of the testes.
Summary · context
We first determined the effects of SR X-ray at the doses of 0, 0.5, 1.3, 4 and 40 Gy on the biochemical and structural properties of the testes one day after SR X-ray exposures.
Report a problemFND-2251827001
02AnimalAnimal study (in vivo)Mechanism
In rat testes, 625 mg/kg NAD significantly decreased double-strand DNA damage induced by 40 Gy SR X-ray.
In plain wordsIn rats, 625 mg/kg NAD reduced testicular DNA damage induced by 40 Gy SR X-ray.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseDouble-strand DNA damage at 625 mg/kg
Study
ratn: not reported in source
Synchrotron radiation X-ray-exposed testes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
625 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
We found that 40 Gy of SR X-ray induced a massive increase in double-strand DNA damage, as assessed by both immunostaining and Western blot of phosphorylated H2AX levels, which was significantly decreased by intraperitoneally (i.p.) administered NAD(+) at doses of 125 and 625 mg/kg.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we used the testes of rats as a model to characterize SR X-ray-induced tissue damage, and to test our hypothesis that NAD(+) administration can prevent SR X-ray-induced injury of the testes.
Summary · context
We first determined the effects of SR X-ray at the doses of 0, 0.5, 1.3, 4 and 40 Gy on the biochemical and structural properties of the testes one day after SR X-ray exposures.
Report a problemFND-2251827002
03AnimalAnimal study (in vivo)Efficacy outcome
In rat testes, NAD ameliorated the SR X-ray-induced increase in abnormal cell nuclei one day after exposure.
In plain wordsIn rats, NAD reduced the increase in abnormal testicular cell nuclei after SR X-ray exposure.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseAbnormal cell nuclei
Study
ratn: not reported in source
Synchrotron radiation X-ray-exposed testes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Forty Gy of SR X-ray can also induce marked increases in abnormal cell nuclei as well as significant decreases in the cell layers of the seminiferous tubules one day after SR X-ray exposures, which were also ameliorated by the NAD(+) administration.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we used the testes of rats as a model to characterize SR X-ray-induced tissue damage, and to test our hypothesis that NAD(+) administration can prevent SR X-ray-induced injury of the testes.
Summary · context
We first determined the effects of SR X-ray at the doses of 0, 0.5, 1.3, 4 and 40 Gy on the biochemical and structural properties of the testes one day after SR X-ray exposures.
Report a problemFND-2251827003
04AnimalAnimal study (in vivo)Efficacy outcome
In rat testes, NAD ameliorated the SR X-ray-induced decrease in seminiferous tubule cell layers one day after exposure.
In plain wordsIn rats, NAD reduced the loss of seminiferous tubule cell layers after SR X-ray exposure.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
IncreaseSeminiferous tubule cell layers
Study
ratn: not reported in source
Synchrotron radiation X-ray-exposed testes
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Forty Gy of SR X-ray can also induce marked increases in abnormal cell nuclei as well as significant decreases in the cell layers of the seminiferous tubules one day after SR X-ray exposures, which were also ameliorated by the NAD(+) administration.
2 context sentences(design, population, supporting numbers)
Summary · context
In this study we used the testes of rats as a model to characterize SR X-ray-induced tissue damage, and to test our hypothesis that NAD(+) administration can prevent SR X-ray-induced injury of the testes.
Summary · context
We first determined the effects of SR X-ray at the doses of 0, 0.5, 1.3, 4 and 40 Gy on the biochemical and structural properties of the testes one day after SR X-ray exposures.
Report a problemFND-2251827004

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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