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Study · Animal study (in vivo) · mouse · 2012

2 results

Expression profiles of carnosine synthesis-related genes in mice after ingestion of carnosine or ß-alanine.

Miyaji T, Sato M, Maemura H, Takahata Y, Morimatsu F

Journal of the International Society of Sports Nutrition17 Apr 2012Cited by 8 (Europe PMC)

PMID22510233 (opens in a new tab)PMCIDPMC3407494 (opens in a new tab)DOI10.1186/1550-2783-9-15 (opens in a new tab)PepBankPUB-22510233
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Summary

BackgroundCarnosine is a dipeptide that improves exercise performance. The carnosine synthesis mechanism through carnosine and ß-alanine ingestion remains unclear. Therefore, we investigated the tissue distribution of carnosine synthase, ATP-grasp domain-containing protein-1 (ATPGD1) mRNA, and ATPGD1 and carnosine specific dipeptidase (CN1) gene expression profiles in mice that were given carnosine or ß-alanine orally.MethodsddY mice (7-week-old) were randomly divided into three groups (n = 6 to 8 animals per group) and were orally given 2 g/kg body weight of carnosine, ß-alanine, or water. After 15, 30, 60, 120, 180, or 360 min of treatment, the tissues (brain, blood, liver, kidneys, olfactory bulbs, hindleg muscles) were collected. The obtained tissues measured the expression of ATPGD1 and CN1 genes using quantitative PCR methods.ResultsThe ATPGD1 gene was expressed in muscle and to a lesser extent in brain. The expression of ATPGD1 in the vastus lateralis muscle increased significantly at 180 min (P = 0.023) after carnosine ingestion and 60 (P = 0.023) and 180 min (P = 0.025) after ß-alanine ingestion. Moreover, the carnosine group showed a significantly increased renal expression of the CN1 gene 60 min after ingestion (P = 0.0015).ConclusionsThe ATPGD1 gene showed high expression levels in brain and muscle. The ß-alanine or carnosine administration significantly increased ATPGD1 and CN1 expression in mice.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In mice, carnosine ingestion significantly increased vastus lateralis ATPGD1 expression at 180 min.

    In plain wordsIn mice, carnosine increased muscle ATPGD1 gene expression at 180 min.

    Peptide
    L-carnosine
    Outcome
    IncreaseMuscle ATPGD1 expression
    Study

    mousen: not reported in source

    ddY mice
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    2 g/kg body weight · oralAs given in this study (mouse).

    Measurements

    Time
    180 min
    after carnosine ingestion
    P value
    0.023
    carnosine

    Source sentences

    Summary
    The expression of ATPGD1 in the vastus lateralis muscle increased significantly at 180 min (P = 0.023) after carnosine ingestion
    1 context sentence
    Summary · context
    ddY mice (7-week-old) were randomly divided into three groups (n = 6 to 8 animals per group) and were orally given 2 g/kg body weight of carnosine, ß-alanine, or water.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, carnosine ingestion significantly increased renal CN1 gene expression at 60 min.

    In plain wordsIn mice, carnosine increased kidney CN1 gene expression at 60 min.

    Peptide
    L-carnosine
    Outcome
    IncreaseRenal CN1 expression
    Study

    mousen: not reported in source

    ddY mice
    Outcome group
    Receptor activity and mechanism · Kidney and urinary
    Studied dose
    2 g/kg body weight · oralAs given in this study (mouse).

    Measurements

    Time
    60 min
    after ingestion
    P value
    0.0015
    carnosine

    Source sentences

    Summary
    Moreover, the carnosine group showed a significantly increased renal expression of the CN1 gene 60 min after ingestion (P = 0.0015).
    1 context sentence
    Summary · context
    ddY mice (7-week-old) were randomly divided into three groups (n = 6 to 8 animals per group) and were orally given 2 g/kg body weight of carnosine, ß-alanine, or water.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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