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Study · Animal study (in vivo) · rat · 2012

6 results

The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors.

Dickson SL, Shirazi RH, Hansson C, Bergquist F, Nissbrandt H, Skibicka KP

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Apr 2012Cited by 353 (Europe PMC)

PMID22492036 (opens in a new tab)PMCIDPMC6620919 (opens in a new tab)DOI10.1523/jneurosci.6326-11.2012 (opens in a new tab)PepBankPUB-22492036
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, exendin‑4 reduced food reward behavior in conditioned place preference testing.

    In plain wordsIn rats, exendin‑4 reduced preference for an environment previously paired with chocolate pellets.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseConditioned place preference
    Study

    ratn: not reported in source

    Food reward paradigms
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Food-reward behavior was reduced in the CPP test by EX4, as rats no longer preferred an environment previously paired to chocolate pellets.
    1 context sentence
    Summary · context
    We assessed the impact of peripheral, central, and intramesolimbic EX4 on two models of food reward: conditioned place preference (CPP) and progressive ratio operant-conditioning.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, peripheral exendin‑4 decreased motivated behavior for sucrose in progressive ratio testing.

    In plain wordsIn rats, peripheral exendin‑4 reduced motivation to obtain sucrose.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseSucrose motivation
    Study

    ratn: not reported in source

    Food reward paradigms
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated · peripheralAs given in this study (rat).

    Source sentences

    Summary
    EX4 also decreased motivated behavior for sucrose in a progressive ratio operant-conditioning paradigm when administered peripherally.
    1 context sentence
    Summary · context
    We assessed the impact of peripheral, central, and intramesolimbic EX4 on two models of food reward: conditioned place preference (CPP) and progressive ratio operant-conditioning.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, central GLP-1 receptors mediated the exendin‑4 effect on food reward.

    In plain wordsIn rats, receptors in the brain mediated the effect of exendin‑4 on food reward.

    Peptide
    Exenatide (exendin-4)
    Outcome
    Not applicableCentral GLP-1 receptor mediation
    Study

    ratn: not reported in source

    Food reward paradigms
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We show that this effect is mediated centrally, via GLP-1 receptors (GLP-1Rs).
    2 context sentences
    Summary · context
    EX4 also decreased motivated behavior for sucrose in a progressive ratio operant-conditioning paradigm when administered peripherally.
    Summary · context
    We assessed the impact of peripheral, central, and intramesolimbic EX4 on two models of food reward: conditioned place preference (CPP) and progressive ratio operant-conditioning.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, exendin‑4 inhibited food reward through the ventral tegmental area and nucleus accumbens.

    In plain wordsIn rats, exendin‑4 reduced food reward through two brain regions.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMesolimbic food reward inhibition
    Study

    ratn: not reported in source

    Food reward paradigms
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that the EX4-mediated inhibition of food reward could be driven from two key mesolimbic structures-ventral tegmental area and nucleus accumbens-without inducing concurrent malaise or locomotor impairment.
    1 context sentence
    Summary · context
    We assessed the impact of peripheral, central, and intramesolimbic EX4 on two models of food reward: conditioned place preference (CPP) and progressive ratio operant-conditioning.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In rats, mesolimbic exendin‑4 inhibition of food reward did not induce concurrent malaise.

    In plain wordsIn rats, exendin‑4 reduced food reward without concurrent malaise.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeMalaise
    Study

    ratn: not reported in source

    Food reward paradigms
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that the EX4-mediated inhibition of food reward could be driven from two key mesolimbic structures-ventral tegmental area and nucleus accumbens-without inducing concurrent malaise or locomotor impairment.
    1 context sentence
    Summary · context
    We assessed the impact of peripheral, central, and intramesolimbic EX4 on two models of food reward: conditioned place preference (CPP) and progressive ratio operant-conditioning.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In rats, mesolimbic exendin‑4 inhibition of food reward did not induce concurrent locomotor impairment.

    In plain wordsIn rats, exendin‑4 reduced food reward without concurrent movement impairment.

    Peptide
    Exenatide (exendin-4)
    Outcome
    No significant changeLocomotor impairment
    Study

    ratn: not reported in source

    Food reward paradigms
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that the EX4-mediated inhibition of food reward could be driven from two key mesolimbic structures-ventral tegmental area and nucleus accumbens-without inducing concurrent malaise or locomotor impairment.
    1 context sentence
    Summary · context
    We assessed the impact of peripheral, central, and intramesolimbic EX4 on two models of food reward: conditioned place preference (CPP) and progressive ratio operant-conditioning.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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