Skip to content

Study · Animal study (in vivo) · rhesus monkey · 2012

3 results

Differential response of the primate HPG axis to N-methyl-D, L-aspartate, but not to Kisspeptin challenge under euglycemic and hypoglycemic conditions.

Wahab F, Zaman WU, Shahab M

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme2 Apr 2012Cited by 5 (Europe PMC)

PMID22473757 (opens in a new tab)DOI10.1055/s-0032-1306309 (opens in a new tab)PepBankPUB-22473757
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In euglycemic male rhesus monkeys, intravenous KP10 significantly stimulated testosterone secretion.

    In plain wordsIn male rhesus monkeys with normal blood sugar, kisspeptin‑10 raised testosterone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTestosterone secretion after KP10 under euglycemia
    Study

    rhesus monkeyn = 5

    chair-restraint habituated adult male rhesus monkeys, euglycemic and insulin-induced hypoglycemic conditions
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    KP10 and NMDA administration stimulated significantly (p<0.005) T secretion in both euglycemic and hypoglycemic monkeys.
    1 context sentence
    Summary · context
    Five intact chair-restraint habituated adult male rhesus monkeys (Macaca mulatta) were given intravenous boli of GnRH, hCG, human kisspeptin-10 (KP10), NMDA (N-methyl-D, L-aspartate, an EAA analogue), and vehicle in both insulin (1 IU/kg)-induced hypoglycemic (IIH) and normal euglycemic conditions.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In insulin-induced hypoglycemic male rhesus monkeys, intravenous KP10 significantly stimulated testosterone secretion.

    In plain wordsIn male rhesus monkeys with low blood sugar, kisspeptin‑10 still raised testosterone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTestosterone secretion after KP10 under hypoglycemia
    Study

    rhesus monkeyn = 5

    chair-restraint habituated adult male rhesus monkeys, euglycemic and insulin-induced hypoglycemic conditions
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    KP10 and NMDA administration stimulated significantly (p<0.005) T secretion in both euglycemic and hypoglycemic monkeys.
    1 context sentence
    Summary · context
    Five intact chair-restraint habituated adult male rhesus monkeys (Macaca mulatta) were given intravenous boli of GnRH, hCG, human kisspeptin-10 (KP10), NMDA (N-methyl-D, L-aspartate, an EAA analogue), and vehicle in both insulin (1 IU/kg)-induced hypoglycemic (IIH) and normal euglycemic conditions.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    Mean testosterone concentrations and AUC after KP10 were comparable between euglycemic and hypoglycemic monkeys.

    In plain wordsIn male rhesus monkeys, the testosterone response to kisspeptin‑10 was similar with normal and with low blood sugar.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePost-KP10 testosterone concentration and AUC, hypoglycemic versus euglycemic
    Study

    rhesus monkeyn = 5

    chair-restraint habituated adult male rhesus monkeys, euglycemic and insulin-induced hypoglycemic conditions
    Comparator
    Euglycemic monkeys
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenous · bolusAs given in this study (rhesus monkey).

    Source sentences

    Summary
    Mean post-KP10 T concentrations and AUC were comparable between euglycemic and hypoglycemic monkeys.
    1 context sentence
    Summary · context
    Five intact chair-restraint habituated adult male rhesus monkeys (Macaca mulatta) were given intravenous boli of GnRH, hCG, human kisspeptin-10 (KP10), NMDA (N-methyl-D, L-aspartate, an EAA analogue), and vehicle in both insulin (1 IU/kg)-induced hypoglycemic (IIH) and normal euglycemic conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.