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Study · Animal study (in vivo) · rat · 2011

2 results

[Evaluation of antiepileptic effects of cortexin in a model of convulsions].

Aniol VA, Novitskaia Iu, Borodina TN, Bukreeva TV, Lazareva NA, Moiseeva IuV, Onufriev MV, Stepanichev MIu, Iakovlev AA, Gekht AB, Granstrem OK, Guliaeva NV

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2011Cited by 1 (Europe PMC)

PMID22433813 (opens in a new tab)PepBankPUB-22433813
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with epileptic status, preliminary cortexin administration had no effect on convulsions.

    In plain wordsIn rats with epileptic status, preliminary cortexin administration had no effect on convulsions.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    No significant changeConvulsions in epileptic status
    Study

    ratn: not reported in source

    pentylenetetrazole-induced epileptic status
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.015, 0.15 and 1.0 mg/kg · intraperitoneal in solution or intranasal with nanoparticles · long-term preliminary administrationAs given in this study (rat).

    Source sentences

    Summary
    In the model of epileptic status, the long-term preliminary administration of cortexin had no effect on convulsions while in the model of chronic convulsions (temporal epilepsy), cortexin had a marked dose-dependent antiepileptic effect.
    1 context sentence
    Summary · context
    We studied antiepileptic effects of cortexin administered in doses 0,015, 0,15 and 1,0 mg/kg intraperitoneally in solution or intranasally in the complex with nanoparticles in a model of acute and chronic convulsions in rats induced by pentylenetetrazole.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with chronic convulsions, cortexin had a marked dose-dependent antiepileptic effect.

    In plain wordsIn rats with chronic convulsions, cortexin had a marked dose-dependent antiepileptic effect.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseChronic convulsions
    Study

    ratn: not reported in source

    pentylenetetrazole-induced chronic convulsions
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    0.015, 0.15 and 1.0 mg/kg · intraperitoneal in solution or intranasal with nanoparticlesAs given in this study (rat).

    Source sentences

    Summary
    In the model of epileptic status, the long-term preliminary administration of cortexin had no effect on convulsions while in the model of chronic convulsions (temporal epilepsy), cortexin had a marked dose-dependent antiepileptic effect.
    1 context sentence
    Summary · context
    We studied antiepileptic effects of cortexin administered in doses 0,015, 0,15 and 1,0 mg/kg intraperitoneally in solution or intranasally in the complex with nanoparticles in a model of acute and chronic convulsions in rats induced by pentylenetetrazole.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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