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Study · Animal study (in vivo) · mouse · 2012

4 results

Reproductive performance and fertility in male and female adult mice chronically treated with hexarelin.

Puechagut PB, Martini AC, Stutz G, Santillán ME, Luque EM, Fiol de Cuneo M, Ruiz RD, Vincenti LM

Reproduction, fertility, and development1 Jan 2012Cited by 10 (Europe PMC)

PMID22401277 (opens in a new tab)DOI10.1071/rd11009 (opens in a new tab)PepBankPUB-22401277
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In female mice treated with hexarelin 200 µg/kg/day for 30 days before mating and in early pregnancy, the ratio of fetuses to corpora lutea fell significantly.

    In plain wordsIn female mice given the higher hexarelin dose, fewer fetuses developed for each egg released.

    Peptide
    Hexarelin
    Outcome
    DecreaseFetuses per corpora lutea ratio
    Study

    mousen: not reported in source

    adult Albino Swiss mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    200 µg/kg/day · subcutaneous · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    We detected a significantly decreased ratio in the number of fetuses per corpora lutea in females treated with HEXr D2 for 30 days before mating and during the first 6 days of pregnancy
    1 context sentence
    Summary · context
    Adult Albino swiss mice were injected (sc) daily with HEXr: 100 μgkg(-1) day(-1) (HEXr D1) or 200 μgkg(-1) day(-1) (HEXr D2) for 53 days in males and 30 days in females.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In female mice, hexarelin at both doses gave only a downward trend in the pregnancy index.

    In plain wordsIn female mice, hexarelin at both doses showed only a downward trend in pregnancy rate.

    Peptide
    Hexarelin
    Outcome
    No significant changePregnancy index in females
    Study

    mousen: not reported in source

    adult Albino Swiss mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 and 200 µg/kg/day · subcutaneous · 30 daysAs given in this study (mouse).

    Source sentences

    Summary
    a downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the analogue.
    1 context sentence
    Summary · context
    Adult Albino swiss mice were injected (sc) daily with HEXr: 100 μgkg(-1) day(-1) (HEXr D1) or 200 μgkg(-1) day(-1) (HEXr D2) for 53 days in males and 30 days in females.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In male mice, hexarelin at both doses gave only a downward trend in the percentage of females impregnated by each male.

    In plain wordsIn male mice, hexarelin at both doses showed only a downward trend in the share of females made pregnant.

    Peptide
    Hexarelin
    Outcome
    No significant changePercentage of females impregnated by each treated male
    Study

    mousen: not reported in source

    adult Albino Swiss mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 and 200 µg/kg/day · subcutaneous · 53 daysAs given in this study (mouse).

    Source sentences

    Summary
    a downward trend in the pregnancy index and percentage of females impregnated by each male treated with both doses of the analogue.
    1 context sentence
    Summary · context
    Adult Albino swiss mice were injected (sc) daily with HEXr: 100 μgkg(-1) day(-1) (HEXr D1) or 200 μgkg(-1) day(-1) (HEXr D2) for 53 days in males and 30 days in females.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In male and female mice, chronic hexarelin had no significant effect on the additional reproductive parameters evaluated.

    In plain wordsIn mice of both sexes, hexarelin had no significant effect on the other reproductive measures checked.

    Peptide
    Hexarelin
    Outcome
    No significant changeAdditional reproductive parameters
    Study

    mousen: not reported in source

    adult Albino Swiss mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    100 and 200 µg/kg/day · subcutaneous · 53 days in males and 30 days in femalesAs given in this study (mouse).

    Source sentences

    Summary
    Although we did not find any significant effect on additional parameters evaluated in both genders
    1 context sentence
    Summary · context
    Adult Albino swiss mice were injected (sc) daily with HEXr: 100 μgkg(-1) day(-1) (HEXr D1) or 200 μgkg(-1) day(-1) (HEXr D2) for 53 days in males and 30 days in females.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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