Developmental increase in kisspeptin-54 release in vivo is independent of the pubertal increase in estradiol in female rhesus monkeys (Macaca mulatta).

Guerriero KA, Keen KL, Terasawa E

Endocrinology7 Feb 2012Cited by 33 (Europe PMC)

PMID22315444PMCIDPMC3320265DOI10.1210/en.2011-1701PepBankPUB-22315444

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Natural levels measured12

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In female rhesus monkeys, mean kisspeptin‑54 release increased from the prepubertal to the pubertal stage.
In plain wordsIn female monkeys, the body's own kisspeptin‑54 release rose as they went through puberty.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMean KP-54 release, pubertal versus prepubertal
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
there was a developmental increase in mean KP-54 release, pulse frequency, and pulse amplitude, which is parallel to the developmental changes in GnRH release that we previously reported.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544401
02AnimalEndogenous levelAnimal study (in vivo)Other
In female rhesus monkeys, kisspeptin‑54 pulse frequency increased from the prepubertal to the pubertal stage.
In plain wordsIn female monkeys, the body's own kisspeptin‑54 pulses became more frequent with puberty.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseKP-54 pulse frequency, pubertal versus prepubertal
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
there was a developmental increase in mean KP-54 release, pulse frequency, and pulse amplitude, which is parallel to the developmental changes in GnRH release that we previously reported.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544402
03AnimalEndogenous levelAnimal study (in vivo)Other
In female rhesus monkeys, kisspeptin‑54 pulse amplitude increased from the prepubertal to the pubertal stage.
In plain wordsIn female monkeys, the body's own kisspeptin‑54 pulses became larger with puberty.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseKP-54 pulse amplitude, pubertal versus prepubertal
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
there was a developmental increase in mean KP-54 release, pulse frequency, and pulse amplitude, which is parallel to the developmental changes in GnRH release that we previously reported.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544403
04AnimalEndogenous levelAnimal study (in vivo)Other
In female rhesus monkeys, a nocturnal increase in kisspeptin‑54 release became prominent after the onset of puberty.
In plain wordsIn female monkeys, the body's own kisspeptin‑54 release rose at night after puberty began.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseNocturnal KP-54 release after puberty onset
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Moreover, a nocturnal increase in KP-54 release becomes prominent after the onset of puberty.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544404
05AnimalEndogenous levelAnimal study (in vivo)Other
In pubertal female rhesus monkeys, ovariectomy enhanced mean kisspeptin‑54 release.
In plain wordsIn pubertal female monkeys, removing the ovaries increased the body's own kisspeptin‑54 release.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMean KP-54 release after ovariectomy in pubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results show that OVX in pubertal monkeys enhanced mean KP-54 release and pulse amplitude but not pulse frequency, whereas OVX did not alter the release pattern of KP-54 in prepubertal monkeys.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544405
06AnimalEndogenous levelAnimal study (in vivo)Other
In pubertal female rhesus monkeys, ovariectomy enhanced kisspeptin‑54 pulse amplitude.
In plain wordsIn pubertal female monkeys, removing the ovaries made the body's own kisspeptin‑54 pulses larger.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseKP-54 pulse amplitude after ovariectomy in pubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results show that OVX in pubertal monkeys enhanced mean KP-54 release and pulse amplitude but not pulse frequency, whereas OVX did not alter the release pattern of KP-54 in prepubertal monkeys.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544406
07AnimalEndogenous levelAnimal study (in vivo)Other
In pubertal female rhesus monkeys, ovariectomy did not change kisspeptin‑54 pulse frequency.
In plain wordsIn pubertal female monkeys, removing the ovaries did not change how often the body's own kisspeptin‑54 pulses occurred.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeKP-54 pulse frequency after ovariectomy in pubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results show that OVX in pubertal monkeys enhanced mean KP-54 release and pulse amplitude but not pulse frequency, whereas OVX did not alter the release pattern of KP-54 in prepubertal monkeys.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544407
08AnimalEndogenous levelAnimal study (in vivo)Other
In prepubertal female rhesus monkeys, ovariectomy did not alter the kisspeptin‑54 release pattern.
In plain wordsIn prepubertal female monkeys, removing the ovaries did not change the body's own kisspeptin‑54 release.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeKP-54 release pattern after ovariectomy in prepubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Results show that OVX in pubertal monkeys enhanced mean KP-54 release and pulse amplitude but not pulse frequency, whereas OVX did not alter the release pattern of KP-54 in prepubertal monkeys.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544408
09AnimalEndogenous levelAnimal study (in vivo)Other
In ovariectomized pubertal rhesus monkeys, estradiol replacement suppressed mean kisspeptin‑54 release.
In plain wordsIn pubertal female monkeys without ovaries, estradiol lowered the body's own kisspeptin‑54 release.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseMean KP-54 release with estradiol replacement in ovariectomized pubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Estradiol replacement in OVX pubertal monkeys suppressed mean KP-54 release and pulse amplitude but not pulse frequency.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544409
10AnimalEndogenous levelAnimal study (in vivo)Other
In ovariectomized pubertal rhesus monkeys, estradiol replacement suppressed kisspeptin‑54 pulse amplitude.
In plain wordsIn pubertal female monkeys without ovaries, estradiol made the body's own kisspeptin‑54 pulses smaller.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseKP-54 pulse amplitude with estradiol replacement in ovariectomized pubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Estradiol replacement in OVX pubertal monkeys suppressed mean KP-54 release and pulse amplitude but not pulse frequency.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544410
11AnimalEndogenous levelAnimal study (in vivo)Other
In ovariectomized pubertal rhesus monkeys, estradiol replacement did not change kisspeptin‑54 pulse frequency.
In plain wordsIn pubertal female monkeys without ovaries, estradiol did not change how often the body's own kisspeptin‑54 pulses occurred.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeKP-54 pulse frequency with estradiol replacement in ovariectomized pubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Estradiol replacement in OVX pubertal monkeys suppressed mean KP-54 release and pulse amplitude but not pulse frequency.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544411
12AnimalEndogenous levelAnimal study (in vivo)Other
In ovariectomized prepubertal rhesus monkeys, estradiol replacement did not alter the kisspeptin‑54 release pattern.
In plain wordsIn prepubertal female monkeys without ovaries, estradiol did not change the body's own kisspeptin‑54 release.
Peptide
Kisspeptin-54 (metastin)
Outcome
No significant changeKP-54 release with estradiol replacement in ovariectomized prepubertal monkeys
Study
rhesus monkey (Macaca mulatta)n: not reported in source
prepubertal and pubertal female rhesus monkeys
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Estradiol replacement in OVX prepubertal monkeys did not alter the KP-54 release pattern.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, to determine the role of KP in puberty, we assessed the in vivo release pattern of KP-54 from the basal hypothalamus/stalk-median eminence in prepubertal and pubertal ovarian-intact female rhesus monkeys.
This result measures the body's own Kisspeptin-54 (metastin). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2231544412

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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