Skip to content

Study · Ex vivo tissue · mouse · 2012

3 results

Expression of the growth hormone/insulin-like growth factor axis during Balb/c thymus ontogeny and effects of growth hormone upon ex vivo T cell differentiation.

Kermani H, Goffinet L, Mottet M, Bodart G, Morrhaye G, Dardenne O, Renard C, Overbergh L, Baron F, Beguin Y, Geenen V, Martens HJ

Neuroimmunomodulation18 Jan 2012Cited by 22 (Europe PMC)

PMID22261974 (opens in a new tab)DOI10.1159/000328844 (opens in a new tab)PepBankPUB-22261974
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In fetal mouse thymus cultures, adding pegvisomant inhibited the GH-induced increase in double negative CD4-CD8- T cells.

    In plain wordsIn lab tests with mouse thymus tissue, pegvisomant inhibited the rise in double negative T cells compared with GH alone.

    Peptide
    Pegvisomant
    Outcome
    DecreaseDouble negative CD4-CD8- T cells
    Study

    mousen: not reported in source

    Fetal thymus organ cultures from Balb/c mice
    Comparator
    GH alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These changes were inhibited by concomitant treatment with GH and the GH receptor (GHR) antagonist pegvisomant.
    3 context sentences
    Summary · context
    In fetal thymus organ cultures (FTOC) derived from Balb/c mice, treatment with exogenous GH resulted in a significant increase of double negative CD4-CD8- T cells and CD4+ T cells, together with a decrease in double positive CD4+CD8+ T cells.
    Summary · context
    The effect of GH on T cell differentiation was explored via thymic organotypic culture.
    Summary · context
    In fetal thymus organ cultures (FTOC) derived from Balb/c mice,
  2. 02LabEx vivo tissueMechanism

    In fetal mouse thymus cultures, adding pegvisomant inhibited the GH-induced increase in CD4+ T cells.

    In plain wordsIn lab tests with mouse thymus tissue, pegvisomant inhibited the rise in CD4+ T cells compared with GH alone.

    Peptide
    Pegvisomant
    Outcome
    DecreaseCD4+ T cells
    Study

    mousen: not reported in source

    Fetal thymus organ cultures from Balb/c mice
    Comparator
    GH alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These changes were inhibited by concomitant treatment with GH and the GH receptor (GHR) antagonist pegvisomant.
    3 context sentences
    Summary · context
    In fetal thymus organ cultures (FTOC) derived from Balb/c mice, treatment with exogenous GH resulted in a significant increase of double negative CD4-CD8- T cells and CD4+ T cells, together with a decrease in double positive CD4+CD8+ T cells.
    Summary · context
    The effect of GH on T cell differentiation was explored via thymic organotypic culture.
    Summary · context
    In fetal thymus organ cultures (FTOC) derived from Balb/c mice,
  3. 03LabEx vivo tissueMechanism

    In fetal mouse thymus cultures, adding pegvisomant inhibited the GH-induced decrease in double positive CD4+CD8+ T cells.

    In plain wordsIn lab tests with mouse thymus tissue, pegvisomant inhibited the fall in double positive T cells compared with GH alone.

    Peptide
    Pegvisomant
    Outcome
    IncreaseDouble positive CD4+CD8+ T cells
    Study

    mousen: not reported in source

    Fetal thymus organ cultures from Balb/c mice
    Comparator
    GH alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These changes were inhibited by concomitant treatment with GH and the GH receptor (GHR) antagonist pegvisomant.
    3 context sentences
    Summary · context
    In fetal thymus organ cultures (FTOC) derived from Balb/c mice, treatment with exogenous GH resulted in a significant increase of double negative CD4-CD8- T cells and CD4+ T cells, together with a decrease in double positive CD4+CD8+ T cells.
    Summary · context
    The effect of GH on T cell differentiation was explored via thymic organotypic culture.
    Summary · context
    In fetal thymus organ cultures (FTOC) derived from Balb/c mice,

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.