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Study · Animal study (in vivo) · mouse · 2012

5 results

NAD(+) administration decreases ischemic brain damage partially by blocking autophagy in a mouse model of brain ischemia.

Zheng C, Han J, Xia W, Shi S, Liu J, Ying W

Neuroscience letters12 Jan 2012Cited by 73 (Europe PMC)

PMID22260797 (opens in a new tab)DOI10.1016/j.neulet.2012.01.007 (opens in a new tab)PepBankPUB-22260797
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with brain ischemia, 50mg/kg NAD significantly decreased infarct size at 48h after ischemia.

    In plain wordsIn mice with brain ischemia, NAD decreased infarct size at 48h.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseInfarct size at 48h
    Study

    mousen: not reported in source

    Transient middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    We found that administration with 50mg/kg NAD(+) led to significant decreases in infarct size, edema formation, and neurological deficits at 48h after ischemia.
    2 context sentences
    Summary · context
    In this study, we used a mouse model of brain ischemia to test our hypothesis that NAD(+) decreases ischemic brain damage partially by preventing autophagy.
    Summary · context
    Adult male mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 90min, and NAD(+) was administered intraperitoneally (i.p.) immediately after reperfusion started.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with brain ischemia, 50mg/kg NAD significantly decreased edema formation at 48h after ischemia.

    In plain wordsIn mice with brain ischemia, NAD decreased swelling at 48h.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseEdema formation at 48h
    Study

    mousen: not reported in source

    Transient middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    We found that administration with 50mg/kg NAD(+) led to significant decreases in infarct size, edema formation, and neurological deficits at 48h after ischemia.
    2 context sentences
    Summary · context
    In this study, we used a mouse model of brain ischemia to test our hypothesis that NAD(+) decreases ischemic brain damage partially by preventing autophagy.
    Summary · context
    Adult male mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 90min, and NAD(+) was administered intraperitoneally (i.p.) immediately after reperfusion started.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with brain ischemia, 50mg/kg NAD significantly decreased neurological deficits at 48h after ischemia.

    In plain wordsIn mice with brain ischemia, NAD decreased neurological deficits at 48h.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseNeurological deficits at 48h
    Study

    mousen: not reported in source

    Transient middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50mg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    We found that administration with 50mg/kg NAD(+) led to significant decreases in infarct size, edema formation, and neurological deficits at 48h after ischemia.
    2 context sentences
    Summary · context
    In this study, we used a mouse model of brain ischemia to test our hypothesis that NAD(+) decreases ischemic brain damage partially by preventing autophagy.
    Summary · context
    Adult male mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 90min, and NAD(+) was administered intraperitoneally (i.p.) immediately after reperfusion started.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, NAD significantly decreased brain ischemia-induced autophagy in the cortex.

    In plain wordsIn mice, NAD reduced autophagy in the cortex after brain ischemia.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseCortical autophagy
    Study

    mousen: not reported in source

    Transient middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    NAD(+) administration also significantly decreased brain ischemia-induced autophagy in the cortex and hippocampus.
    2 context sentences
    Summary · context
    In this study, we used a mouse model of brain ischemia to test our hypothesis that NAD(+) decreases ischemic brain damage partially by preventing autophagy.
    Summary · context
    Adult male mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 90min, and NAD(+) was administered intraperitoneally (i.p.) immediately after reperfusion started.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice, NAD significantly decreased brain ischemia-induced autophagy in the hippocampus.

    In plain wordsIn mice, NAD reduced autophagy in the hippocampus after brain ischemia.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseHippocampal autophagy
    Study

    mousen: not reported in source

    Transient middle cerebral artery occlusion
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    NAD(+) administration also significantly decreased brain ischemia-induced autophagy in the cortex and hippocampus.
    2 context sentences
    Summary · context
    In this study, we used a mouse model of brain ischemia to test our hypothesis that NAD(+) decreases ischemic brain damage partially by preventing autophagy.
    Summary · context
    Adult male mice were subjected to transient middle cerebral artery occlusion (tMCAO) for 90min, and NAD(+) was administered intraperitoneally (i.p.) immediately after reperfusion started.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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