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Study · Measured the body's own peptide · 2011

4 results

Thymosin beta4 levels after successful primary percutaneous coronary intervention for acute myocardial infarction.

Yeşilay AB, Karakurt O, Akdemir R, Erden G, Kılıç H, Açıkel S, Karasu B, Sarı M, Balcı M, Aksoy M

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir1 Dec 2011Cited by 3 (Europe PMC)

PMID22257803 (opens in a new tab)DOI10.5543/tkda.2011.01751 (opens in a new tab)PepBankPUB-22257803
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with ST-elevation myocardial infarction, baseline serum Tβ4 was lower than in healthy controls.

    In plain wordsIn people with a heart attack, the body's own Tβ4 level was lower than in healthy people at admission.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseSerum Tβ4 at admission, STEMI patients versus controls
    Study

    n = 48

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Cardiovascular

    Measurements

    Serum Tβ4
    2.9 µg/ml
    controls
    Serum Tβ4
    1.5 µg/ml
    STEMI at baseline

    Source sentences

    Summary
    Compared to controls, baseline levels of high-density lipoprotein cholesterol (46.2±8.9 vs. 34.2±7.2 mg/dl, p<0.001) and Tβ4 (2.9±1.5 vs. 1.5±1.0 µg/ml, p<0.001) were significantly lower, and white blood cell counts (7.6±2.2 vs. 11.4±3.0 10³/µl, p<0.001) were significantly higher in the STEMI group.
    2 context sentences
    Summary · context
    The study included 24 consecutive patients (7 females, 17 males; mean age 55.0±10.9 years) who underwent successful primary PCI for STEMI and 24 age- and sex-matched healthy controls (13 females, 11 males; mean age 57.5±11.7 years) with angiographically normal coronary arteries.
    Summary · context
    To determine Tβ4 levels, blood samples were obtained from STEMI patients on admission and 48 hours after successful PCI, and from controls immediately after coronary angiography.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    After 48 hours of PCI, serum Tβ4 in STEMI patients was similar to that of controls.

    In plain wordsAfter the procedure, the body's own Tβ4 level in heart attack patients became similar to the level in healthy controls.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeSerum Tβ4 after PCI versus controls
    Study

    n = 48

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Cardiovascular

    Source sentences

    Summary
    became similar to that of the control group (p=0.068).
    2 context sentences
    Summary · context
    The study included 24 consecutive patients (7 females, 17 males; mean age 55.0±10.9 years) who underwent successful primary PCI for STEMI and 24 age- and sex-matched healthy controls (13 females, 11 males; mean age 57.5±11.7 years) with angiographically normal coronary arteries.
    Summary · context
    To determine Tβ4 levels, blood samples were obtained from STEMI patients on admission and 48 hours after successful PCI, and from controls immediately after coronary angiography.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In STEMI patients, serum Tβ4 rose significantly 48 hours after successful primary PCI.

    In plain wordsIn people with a heart attack, the body's own Tβ4 level rose 48 hours after a successful procedure to open the artery.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSerum Tβ4 48 hours after successful PCI
    Study

    n = 24

    Comparator
    Baseline (admission)
    Outcome group
    Endogenous peptide levels · Cardiovascular

    Measurements

    Serum Tβ4
    2.3 µg/ml
    48 hours after PCI

    Source sentences

    Summary
    After 48 hours of PCI, the mean Tβ4 level increased significantly to 2.3±0.8 µg/ml (p<0.001) and became similar to that of the control group (p=0.068).
    2 context sentences
    Summary · context
    The study included 24 consecutive patients (7 females, 17 males; mean age 55.0±10.9 years) who underwent successful primary PCI for STEMI and 24 age- and sex-matched healthy controls (13 females, 11 males; mean age 57.5±11.7 years) with angiographically normal coronary arteries.
    Summary · context
    To determine Tβ4 levels, blood samples were obtained from STEMI patients on admission and 48 hours after successful PCI, and from controls immediately after coronary angiography.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    Across the study participants (24 patients with STEMI and 24 controls), serum Tβ4 correlated negatively with white blood cell count (r=-0.347).

    In plain wordsIn this study, people with higher natural Tβ4 levels in the blood tended to have lower white blood cell counts.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableCorrelation of serum Tβ4 with white blood cell count
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Cardiovascular

    Measurements

    Correlation coefficient r
    −0.347 r
    serum Tβ4 vs white blood cell count

    Source sentences

    Summary
    There was a significant negative correlation between serum Tβ4 and white blood cell count (r=-0.347, p=0.016).
    2 context sentences
    Summary · context
    The study included 24 consecutive patients (7 females, 17 males; mean age 55.0±10.9 years) who underwent successful primary PCI for STEMI and 24 age- and sex-matched healthy controls (13 females, 11 males; mean age 57.5±11.7 years) with angiographically normal coronary arteries.
    Summary · context
    To determine Tβ4 levels, blood samples were obtained from STEMI patients on admission and 48 hours after successful PCI, and from controls immediately after coronary angiography.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

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