Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB.

Velmurugan K, Balamurugan AN, Loganathan G, Ahmad A, Hering BJ, Pugazhenthi S

Endocrinology17 Jan 2012Cited by 46 (Europe PMC)

PMID22253425DOI10.1210/en.2011-1895PepBankPUB-22253425

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

01AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Efficacy outcome
In diabetic athymic nude mice, transplantation of CREB-transduced, exendin‑4-treated human islets improved glycemic control over 30 days.
In plain wordsIn mice with diabetes, transplanted human islets treated with CREB gene transfer and exendin‑4 improved blood sugar control.
Peptide
Exenatide (exendin-4)
Outcome
MixedGlycemic control after islet transplantation
Study
micen: not reported in source
Diabetic athymic nude mice receiving human islets
Outcome group
Glycemic control · Metabolic and weight
Source sentences
Summary
More significantly, transplantation of human islets transduced with adenoviral CREB and treated with exendin-4 showed improved glycemic control over a 30-d period in diabetic athymic nude mice.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342508
02LabNot a test of Exenatide (exendin-4) aloneEx vivo tissueMechanism
In cultured human islets, adenoviral CREB with exendin‑4 increased insulin receptor substrate-2 protein.
In plain wordsIn lab tests, CREB gene transfer with exendin‑4 increased insulin receptor substrate-2 protein in human islets.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseInsulin receptor substrate-2 protein
Study
humann: not reported in source
Cultured human islets
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
This combination increased the levels of several proteins needed for β-cell survival and function, including insulin receptor substrate-2, Bcl-2, and baculoviral IAP repeat-containing 3, and suppressed the expression of proapoptotic and inflammatory genes.
1 context sentence(design, population, supporting numbers)
Summary · context
Islets were transduced with adenoviral CREB followed by exposure to exendin-4 as a strategy for improving their survival.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342501
03LabNot a test of Exenatide (exendin-4) aloneEx vivo tissueMechanism
In cultured human islets, adenoviral CREB with exendin‑4 increased Bcl-2 protein.
In plain wordsIn lab tests, CREB gene transfer with exendin‑4 increased Bcl-2 protein in human islets.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseBcl-2 protein
Study
humann: not reported in source
Cultured human islets
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
This combination increased the levels of several proteins needed for β-cell survival and function, including insulin receptor substrate-2, Bcl-2, and baculoviral IAP repeat-containing 3, and suppressed the expression of proapoptotic and inflammatory genes.
1 context sentence(design, population, supporting numbers)
Summary · context
Islets were transduced with adenoviral CREB followed by exposure to exendin-4 as a strategy for improving their survival.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342502
04LabNot a test of Exenatide (exendin-4) aloneEx vivo tissueMechanism
In cultured human islets, adenoviral CREB with exendin‑4 increased baculoviral IAP repeat-containing 3 protein.
In plain wordsIn lab tests, CREB gene transfer with exendin‑4 increased baculoviral IAP repeat-containing 3 protein in human islets.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseBaculoviral IAP repeat-containing 3 protein
Study
humann: not reported in source
Cultured human islets
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
This combination increased the levels of several proteins needed for β-cell survival and function, including insulin receptor substrate-2, Bcl-2, and baculoviral IAP repeat-containing 3, and suppressed the expression of proapoptotic and inflammatory genes.
1 context sentence(design, population, supporting numbers)
Summary · context
Islets were transduced with adenoviral CREB followed by exposure to exendin-4 as a strategy for improving their survival.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342503
05LabNot a test of Exenatide (exendin-4) aloneEx vivo tissueMechanism
In cultured human islets, adenoviral CREB with exendin‑4 suppressed proapoptotic gene expression.
In plain wordsIn lab tests, CREB gene transfer with exendin‑4 reduced expression of cell-death genes in human islets.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseProapoptotic gene expression
Study
humann: not reported in source
Cultured human islets
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
This combination increased the levels of several proteins needed for β-cell survival and function, including insulin receptor substrate-2, Bcl-2, and baculoviral IAP repeat-containing 3, and suppressed the expression of proapoptotic and inflammatory genes.
1 context sentence(design, population, supporting numbers)
Summary · context
Islets were transduced with adenoviral CREB followed by exposure to exendin-4 as a strategy for improving their survival.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342504
06LabNot a test of Exenatide (exendin-4) aloneEx vivo tissueMechanism
In cultured human islets, adenoviral CREB with exendin‑4 suppressed inflammatory gene expression.
In plain wordsIn lab tests, CREB gene transfer with exendin‑4 reduced inflammatory gene expression in human islets.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseInflammatory gene expression
Study
humann: not reported in source
Cultured human islets
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
This combination increased the levels of several proteins needed for β-cell survival and function, including insulin receptor substrate-2, Bcl-2, and baculoviral IAP repeat-containing 3, and suppressed the expression of proapoptotic and inflammatory genes.
1 context sentence(design, population, supporting numbers)
Summary · context
Islets were transduced with adenoviral CREB followed by exposure to exendin-4 as a strategy for improving their survival.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342505
07LabNot a test of Exenatide (exendin-4) aloneEx vivo tissueEfficacy outcome
In cultured human islets, CREB with exendin‑4 enhanced protection against hypoxia-induced apoptosis.
In plain wordsIn lab tests, CREB with exendin‑4 enhanced protection of human islets against cell death from low oxygen.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseApoptosis under hypoxia
Study
humann: not reported in source
Cultured human islets
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
A combination of CREB and exendin-4 exerted enhanced antiapoptotic action in cultured islets against hypoxia and cytokines.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342506
08LabNot a test of Exenatide (exendin-4) aloneEx vivo tissueEfficacy outcome
In cultured human islets, CREB with exendin‑4 enhanced protection against cytokine-induced apoptosis.
In plain wordsIn lab tests, CREB with exendin‑4 enhanced protection of human islets against cytokine-induced cell death.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseApoptosis under cytokines
Study
humann: not reported in source
Cultured human islets
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
A combination of CREB and exendin-4 exerted enhanced antiapoptotic action in cultured islets against hypoxia and cytokines.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2225342507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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