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Study · In vitro (cells) · rat · 2012

2 results

An AD-related neuroprotector rescues transformed rat retinal ganglion cells from CoCl₂-induced apoptosis.

Men J, Zhang X, Yang Y, Gao D

Journal of molecular neuroscience : MN5 Jan 2012Cited by 20 (Europe PMC)

PMID22222604 (opens in a new tab)DOI10.1007/s12031-011-9701-5 (opens in a new tab)PepBankPUB-22222604
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In RGC-5 cells exposed to CoCl₂, humanin attenuated the CoCl₂-induced loss of cell viability.

    In plain wordsIn rat retinal cells in a dish, humanin reduced the loss of cell survival caused by a hypoxia-mimicking chemical.

    Peptide
    Humanin
    Outcome
    DecreaseCell viability loss with CoCl₂
    Study

    ratn: not reported in source

    RGC-5 retinal ganglion cells, CoCl2 hypoxia mimetic
    Comparator
    CoCl2 without humanin
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hypoxia mimetic compound cobalt chloride (CoCl₂) could increase the cell viability loss and apoptosis, whereas HN can significantly attenuate these effects.
    2 context sentences
    Title · context
    An AD-related neuroprotector rescues transformed rat retinal ganglion cells from CoCl₂-induced apoptosis.
    Summary · context
    In present study, we investigated the neuroprotective effects of HN on hypoxia-induced toxicity in RGC-5 cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In RGC-5 cells exposed to CoCl₂, humanin attenuated the CoCl₂-induced apoptosis.

    In plain wordsIn rat retinal cells in a dish, humanin reduced the cell death caused by a hypoxia-mimicking chemical.

    Peptide
    Humanin
    Outcome
    DecreaseApoptosis with CoCl₂
    Study

    ratn: not reported in source

    RGC-5 retinal ganglion cells, CoCl2 hypoxia mimetic
    Comparator
    CoCl2 without humanin
    Outcome group
    Neuroprotection · Eye
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Hypoxia mimetic compound cobalt chloride (CoCl₂) could increase the cell viability loss and apoptosis, whereas HN can significantly attenuate these effects.
    2 context sentences
    Title · context
    An AD-related neuroprotector rescues transformed rat retinal ganglion cells from CoCl₂-induced apoptosis.
    Summary · context
    In present study, we investigated the neuroprotective effects of HN on hypoxia-induced toxicity in RGC-5 cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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