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Study · Not a test of the peptide alone · 2012

7 results

Thymosin beta 4 is dispensable for murine cardiac development and function.

Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J

Circulation research8 Dec 2011Cited by 52 (Europe PMC)

PMID22158707 (opens in a new tab)PMCIDPMC3739283 (opens in a new tab)DOI10.1161/circresaha.111.258616 (opens in a new tab)PepBankPUB-22158707
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    Global tβ4-knockout mice were born at mendelian ratios and had normal heart and blood vessel formation.

    In plain wordsIn mice, losing the Tβ4 gene did not change birth ratios or heart and blood vessel formation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeBirth ratio and heart and vessel formation in global knockout
    Study

    mousen: not reported in source

    global and cardiac-specific tβ4-knockout
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Global tβ4-knockout mice were born at mendelian ratios and exhibited normal heart and blood vessel formation.
    1 context sentence
    Summary · context
    We examined the role of Tβ4 in developing and adult heart through global and cardiac specific tβ4-knockout mouse models.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In adult global tβ4-knockout mice, cardiac function was indistinguishable from controls.

    In plain wordsIn adult mice, losing the Tβ4 gene did not change heart function compared with normal mice.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCardiac function in adult global knockout
    Study

    mousen: not reported in source

    global and cardiac-specific tβ4-knockout
    Comparator
    Control mice
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    in adult global tβ4-knockout mice, cardiac function, capillary density, expression of key cardiac fetal and angiogenic genes, epicardial marker expression, and extracellular matrix deposition were indistinguishable from that of controls
    1 context sentence
    Summary · context
    We examined the role of Tβ4 in developing and adult heart through global and cardiac specific tβ4-knockout mouse models.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In adult global tβ4-knockout mice, capillary density was indistinguishable from controls.

    In plain wordsIn adult mice, losing the Tβ4 gene did not change capillary density compared with normal mice.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCapillary density in adult global knockout
    Study

    mousen: not reported in source

    global and cardiac-specific tβ4-knockout
    Comparator
    Control mice
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    in adult global tβ4-knockout mice, cardiac function, capillary density, expression of key cardiac fetal and angiogenic genes, epicardial marker expression, and extracellular matrix deposition were indistinguishable from that of controls
    1 context sentence
    Summary · context
    We examined the role of Tβ4 in developing and adult heart through global and cardiac specific tβ4-knockout mouse models.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In adult global tβ4-knockout mice, expression of key cardiac fetal and angiogenic genes was indistinguishable from controls.

    In plain wordsIn adult mice, losing the Tβ4 gene did not change key heart and blood vessel gene activity compared with normal mice.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCardiac fetal and angiogenic gene expression in adult global knockout
    Study

    mousen: not reported in source

    global and cardiac-specific tβ4-knockout
    Comparator
    Control mice
    Outcome group
    Gene expression · Cardiovascular

    Source sentences

    Summary
    in adult global tβ4-knockout mice, cardiac function, capillary density, expression of key cardiac fetal and angiogenic genes, epicardial marker expression, and extracellular matrix deposition were indistinguishable from that of controls
    1 context sentence
    Summary · context
    We examined the role of Tβ4 in developing and adult heart through global and cardiac specific tβ4-knockout mouse models.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In adult global tβ4-knockout mice, epicardial marker expression was indistinguishable from controls.

    In plain wordsIn adult mice, losing the Tβ4 gene did not change outer heart layer markers compared with normal mice.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeEpicardial marker expression in adult global knockout
    Study

    mousen: not reported in source

    global and cardiac-specific tβ4-knockout
    Comparator
    Control mice
    Outcome group
    Gene expression · Cardiovascular

    Source sentences

    Summary
    in adult global tβ4-knockout mice, cardiac function, capillary density, expression of key cardiac fetal and angiogenic genes, epicardial marker expression, and extracellular matrix deposition were indistinguishable from that of controls
    1 context sentence
    Summary · context
    We examined the role of Tβ4 in developing and adult heart through global and cardiac specific tβ4-knockout mouse models.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  6. 06AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In adult global tβ4-knockout mice, extracellular matrix deposition was indistinguishable from controls.

    In plain wordsIn adult mice, losing the Tβ4 gene did not change tissue scaffold build-up in the heart compared with normal mice.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeExtracellular matrix deposition in adult global knockout
    Study

    mousen: not reported in source

    global and cardiac-specific tβ4-knockout
    Comparator
    Control mice
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    in adult global tβ4-knockout mice, cardiac function, capillary density, expression of key cardiac fetal and angiogenic genes, epicardial marker expression, and extracellular matrix deposition were indistinguishable from that of controls
    1 context sentence
    Summary · context
    We examined the role of Tβ4 in developing and adult heart through global and cardiac specific tβ4-knockout mouse models.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  7. 07AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    Tissue-specific tβ4-deficient mice, made with Nkx2.5-Cre and αMHC-Cre, had no phenotype.

    In plain wordsIn mice, losing the Tβ4 gene only in heart tissue caused no visible change.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changePhenotype of tissue-specific tβ4-deficient mice
    Study

    mousen: not reported in source

    global and cardiac-specific tβ4-knockout
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    Tissue-specific tβ4-deficient mice, generated by crossing tβ4-floxed mice to Nkx2.5-Cre and αMHC-Cre, were also found to have no phenotype.
    1 context sentence
    Summary · context
    We examined the role of Tβ4 in developing and adult heart through global and cardiac specific tβ4-knockout mouse models.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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